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More importantly, in preclinical ferret models, the bsAb N2D2-Fc-N2C1 conferred complete protection against SFTSV not only at a low dose of 5 mg\/kg but also when administered as late as 2 d postinfection. These results demonstrate the potent protective efficacy of N2D2-Fc-N2C1, supporting its development as a promising clinical candidate against SFTSV infection.<\/jats:p>","DOI":"10.1073\/pnas.2613799123","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:13:32Z","timestamp":1790784812000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["A highly potent bispecific antibody confers complete protection against SFTSV in preclinical models"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2796-0601","authenticated-orcid":false,"given":"Xiaoping","family":"Guo","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04c4dkn09","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Disease, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University 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