{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:42:06Z","timestamp":1790181726768,"version":"4.1.0"},"reference-count":109,"publisher":"National Academy of Sciences","issue":"25","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["2R01AI089894-18"],"award-info":[{"award-number":["2R01AI089894-18"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI126887"],"award-info":[{"award-number":["AI126887"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["5I01BX001469"],"award-info":[{"award-number":["5I01BX001469"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32AI007172"],"award-info":[{"award-number":["T32AI007172"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,6,23]]},"abstract":"<jats:p>\n                    Enterotoxigenic\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    (ETEC) and\n                    <jats:italic toggle=\"yes\">Shigella<\/jats:italic>\n                    are the most common bacterial diarrheal pathogens among young children of low-middle income regions. Enteric pathogens must overcome formidable host defenses, including the protective barrier formed by intestinal mucus. ETEC produce a virulence protein called EatA, a member of the Serine Protease Autotransporter of the\n                    <jats:italic toggle=\"yes\">Enterobacteriae<\/jats:italic>\n                    (SPATE) family, where the secreted passenger domain (EatA\n                    <jats:sub>p<\/jats:sub>\n                    ) specifically degrades MUC2, the major mucus secreted by goblet cells of the human intestine. Notably, some\n                    <jats:italic toggle=\"yes\">Shigella<\/jats:italic>\n                    spp., as well as other diarrheagenic\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    pathovars, secrete homologues of EatA known as SepA, and Pic. Here, we demonstrate that EatA, SepA, and Pic are functionally redundant MUC2 mucinases and that recombinant monoclonal antibodies (mAbs) derived from plasmablasts of ETEC-infected humans can inhibit MUC2 degradation by all three proteases. We present cryo-EM structures of EatA and the related SPATE proteins, SepA, and Pic, complexed to fragment antigen-binding portions of these mAbs to demonstrate that those targeting a core \u03b2-helix epitope shared by all three SPATE molecules broadly neutralize the capacity to degrade MUC2. These mAbs effectively prevent MUC2 degradation by each SPATE as well as mucus penetration by ETEC,\n                    <jats:italic toggle=\"yes\">Shigella flexneri<\/jats:italic>\n                    , and Pic-producing enteroaggregative\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    (EAEC). We anticipate that these studies could facilitate rational design of vaccines that broadly protect against major enteric pathogens by targeting a shared virulence feature.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2614012123","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:02:12Z","timestamp":1781550132000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["Human enterotoxigenic\n                    <i>Escherichia coli<\/i>\n                    (ETEC) infections elicit antibodies that broadly neutralize mucinases of pathogenic\n                    <i>Escherichia coli<\/i>\n                    and\n                    <i>Shigella<\/i>"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1582-5983","authenticated-orcid":false,"given":"David P.","family":"Buckley","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02ymw8z06","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, University of Missouri Columbia","place":["Columbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjahan","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine","place":["St. Louis"]},{"id":[{"id":"https:\/\/ror.org\/04vsvr128","id-type":"ROR","asserted-by":"publisher"}],"name":"Mucosal Immunology and Vaccinology Unit, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahima","family":"Thapa","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University in Saint Louis, School of Medicine","place":["Saint Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University in Saint Louis, School of Medicine","place":["Saint Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4396-6265","authenticated-orcid":false,"given":"Jackson","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University in Saint Louis, School of Medicine","place":["Saint Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.","family":"Vickers","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine","place":["St. Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazia","family":"Khatoon","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine","place":["St. Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Hasanul","family":"Kaisar","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine","place":["St. Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Coggin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine","place":["St. Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debayan","family":"Ganguli","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine","place":["St. Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2972-6978","authenticated-orcid":false,"given":"Alaullah","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine","place":["St. Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee M.","family":"Laird","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05f421b09","id-type":"ROR","asserted-by":"publisher"}],"name":"Military Relevant Bacterial Diseases Department, Naval Medical Research Command","place":["Silver Spring"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Poly","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05f421b09","id-type":"ROR","asserted-by":"publisher"}],"name":"Military Relevant Bacterial Diseases Department, Naval Medical Research Command","place":["Silver Spring"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad K.","family":"Porter","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05f421b09","id-type":"ROR","asserted-by":"publisher"}],"name":"Translational and Clinical Research Department, Naval Medical Research Command","place":["Silver Spring"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Ruiz-Perez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0153tk833","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatrics, University of Virginia School of Medicine","place":["Charlottesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine","place":["St. Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahima","family":"Chowdhury","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04vsvr128","id-type":"ROR","asserted-by":"publisher"}],"name":"Mucosal Immunology and Vaccinology Unit, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3755-4763","authenticated-orcid":false,"given":"Tafiqur R.","family":"Bhuiyan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04vsvr128","id-type":"ROR","asserted-by":"publisher"}],"name":"Mucosal Immunology and Vaccinology Unit, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firdausi","family":"Qadri","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04vsvr128","id-type":"ROR","asserted-by":"publisher"}],"name":"Mucosal Immunology and Vaccinology Unit, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3135-9134","authenticated-orcid":false,"given":"Sergio","family":"Trillo-Muyo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01tm6cn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biochemistry and Cell Biology, University of Gothenburg","place":["Gothenburg, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9062-3882","authenticated-orcid":false,"given":"Brendan","family":"Dolan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01tm6cn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biochemistry and Cell Biology, University of Gothenburg","place":["Gothenburg, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7965-5311","authenticated-orcid":false,"given":"Sjoerd","family":"van der Post","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01tm6cn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biochemistry and Cell Biology, University of Gothenburg","place":["Gothenburg, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ellebedy","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University in Saint Louis, School of Medicine","place":["Saint Louis"]},{"name":"Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine","place":["St. Louis"]},{"name":"The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine","place":["St. Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary T.","family":"Berndsen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02ymw8z06","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, University of Missouri Columbia","place":["Columbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1148-697X","authenticated-orcid":false,"given":"James M.","family":"Fleckenstein","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine","place":["St. Louis"]},{"name":"Infectious Diseases, Medicine Service, Veterans Affairs Saint Louis Health Care System","place":["Saint Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30475-4"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20-0053"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/tax003"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60844-2"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiae446"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30076-2"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.13002"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab434"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00459-07"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.73.6.799"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30483-2"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005586"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2023.11.001"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01890-14"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.4.2245-2258.2006"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00736.x"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2009.10.002"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftz054"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12182"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006451107"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600623103"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.30.18857"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208483200"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.35"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00572-21"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00551-13"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00740-18"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.3.1786-1794.2004"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.8.3.322-328.1973"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01078-13"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37666-8"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","unstructured":"S. Trillo-Muyo EatA mediated degradation of intestinal mucus is species-specific and driven by MUC2 structural features. Nat. Commun. 17 158 (2026).","DOI":"10.1038\/s41467-025-68037-0"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007825"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2005.03.007"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00041-21"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11092221"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-144-7-1815"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1995.mmi_17010123.x"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179238"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106920"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir757"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008613"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2019.1632062"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004713"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2319951121"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02833-21"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00045"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67104-4"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.11.5587-5596.1999"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy312"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-019-0131-7"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003446"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00260-18"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.614372"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.459479"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-68037-0"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaj1879"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav9033"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2017.1339006"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.esp-0031-2018"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507923103"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910036966"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412885200"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.04.041"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.279"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.09.028"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.02.016"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad398"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.04.018"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq399"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.05.022"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2023.02.011"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2022.12.037"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2023.102372"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.04.018"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10091376"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(24)00092-5"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00850-X"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines13050513"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10020340"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8040689"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13067"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00004-25"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2538"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-025-02218-x"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.104994"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftw054"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2017.02.018"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.80.294"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.12.7105-7113.2002"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.05.005"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis238"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2419457122"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.003"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.7.3155-3163.1998"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/26.9.1255"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97659"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02021-16"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12020288"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012241"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000583"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2016.09.001"},{"key":"e_1_3_4_104_2","doi-asserted-by":"crossref","unstructured":"D. P. Buckley Z. T. Berndsen Cryo-EM structure of Enterotoxigenic Escherichia coli autotransporter A (EatA) complexed with the fragment antigen binding domain of monoclonal antibody 25. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9Z76. Deposited 16 November 2025.","DOI":"10.2210\/pdb9z76\/pdb"},{"key":"e_1_3_4_105_2","doi-asserted-by":"crossref","unstructured":"D. P. Buckley Z. T. Berndsen Cryo-EM structure of Enterotoxigenic Escherichia coli autotransporter A (EatA) complexed with the fragment antigen binding domain of monoclonal antibody G12. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9Z77. Deposited 16 November 2025.","DOI":"10.2210\/pdb9z77\/pdb"},{"key":"e_1_3_4_106_2","doi-asserted-by":"crossref","unstructured":"D. P. Buckley Z. T. Berndsen Cryo-EM structure of Enterotoxigenic Escherichia coli autotransporter A(EatA) complexed with the fragment antigen binding domain of monoclonal antibody 15. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9Z78. Deposited 16 November 2025.","DOI":"10.2210\/pdb9z78\/pdb"},{"key":"e_1_3_4_107_2","doi-asserted-by":"crossref","unstructured":"D. P. Buckley Z. T. Berndsen Cryo-EM structure of Enterotoxigenic Escherichia coli autotransporter A (EatA) complexed with the fragment antigen binding domain of monoclonal antibody 40. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9Z79. Deposited 16 Noevember 2025.","DOI":"10.2210\/pdb9z79\/pdb"},{"key":"e_1_3_4_108_2","doi-asserted-by":"crossref","unstructured":"D. P. Buckley Z. T. Berndsen Cryo-EM structure of Secreted extracellular protein A (SepA) from Shigella flexneri complexed with the fragment antigen binding domain of monoclonal antibody 40. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9Z7A. Deposited 16 November 2025.","DOI":"10.2210\/pdb9z7a\/pdb"},{"key":"e_1_3_4_109_2","doi-asserted-by":"crossref","unstructured":"D. P. Buckley Z. T. Berndsen Cryo-EM structure of Protein involved in colonization (Pic) from Enteroaggregative Escherichia coli complexed with the fragment antigen binding domain of monoclonal antibody 40. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9Z7B. Deposited 16 November 2025.","DOI":"10.2210\/pdb9z7b\/pdb"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2614012123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:03:03Z","timestamp":1781550183000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2614012123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":109,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2026,6,23]]}},"alternative-id":["10.1073\/pnas.2614012123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2614012123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"assertion":[{"value":"2026-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2614012123"}}