{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:53:55Z","timestamp":1792785235560,"version":"4.5.0"},"reference-count":48,"publisher":"National Academy of Sciences","issue":"40","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NSF of China","award":["32271356"],"award-info":[{"award-number":["32271356"]}]},{"name":"Fundamental Research Funds for Central Universities","award":["2042024kf0027"],"award-info":[{"award-number":["2042024kf0027"]}]},{"name":"Funds of Taikang Center for Life and Medical Sciences","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Startup Funds of Wuhan University","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"https:\/\/ror.org\/033vjfk17","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NSF of China","award":["62202343"],"award-info":[{"award-number":["62202343"]}]},{"name":"Fundamental Research Funds for Central Universities","award":["2042026kf0023"],"award-info":[{"award-number":["2042026kf0023"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:p>\n                    Sebaceous glands (SGs) are essential for maintaining skin homeostasis and barrier function. However, the cell biology and lineage of SGs remain poorly understood in vivo. Here we performed bulk isolation of murine SGs, uncovered their molecular features, and generated SG-specific tool mouse models. Tracing with SG-Chaser mice revealed SG heterogeneity and their dynamic and distinct responses to common external stimuli. Specifically, some SG stem cell (SGSC) descendants homed back to the bulge and underwent redifferentiation, the toggling of which is critical for preserving stem cell pool and maintaining SG homeostasis. Combining single-cell RNA sequencing with lineage tracing, we identified the origin of murine SGs and found that\n                    <jats:italic toggle=\"yes\">Krt15<\/jats:italic>\n                    + cells gave rise to both typical and atypical SGs via divergent differentiation trajectories. As lipid-rich cells, murine sebocytes exhibit a differentiation program closely resembling that of adipocytes and highly reliant on Ppar\u03b3. Topical pharmacological regulation of Ppar\u03b3 can effectively modulate sebocytes homeostasis in both mice and humans. Together, these results unveil the multilayered dynamics of murine SGs and suggest viable approaches to modulate SG homeostasis and maintain barrier integrity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2615179123","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:15:22Z","timestamp":1790961322000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Lineage and renewal dynamics of sebaceous glands govern skin barrier integrity in mice"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6680-7846","authenticated-orcid":false,"given":"Xichen","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Metabolism and Regulation in Complex Organisms, Taikang Center for Life and Medical Sciences, Hubei Provincial Research Center for Basic Biological Sciences, Hubei Key Laboratory of Cell Homeostasis, Department of 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolism and Regulation in Complex Organisms, Taikang Center for Life and Medical Sciences, Hubei Provincial Research Center for Basic Biological Sciences, Hubei Key Laboratory of Cell Homeostasis, Department of Biochemistry, College of Life Sciences, Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Yi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01v5mqw79","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Dermatology, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2224-4287","authenticated-orcid":false,"given":"Qiong Annabel","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope Medical Center","place":["Duarte"]},{"id":[{"id":"https:\/\/ror.org\/05fazth07","id-type":"ROR","asserted-by":"publisher"}],"name":"Comprehensive Cancer Center, Beckman Research Institute, City of Hope Medical Center","place":["Duarte"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7771-4181","authenticated-orcid":false,"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metabolism and Regulation in Complex Organisms, Taikang Center for Life and Medical Sciences, Hubei Provincial Research Center for Basic Biological Sciences, Hubei Key Laboratory of Cell Homeostasis, Department of Biochemistry, College of Life Sciences, Wuhan University","place":["Wuhan, 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and dermatology: The role of dietary intervention in skin disease","volume":"7","author":"Katta R.","year":"2014","unstructured":"R. Katta, S. P. Desai, Diet and dermatology: The role of dietary intervention in skin disease. J. Clin. Aesthet. Dermatol. 7, 46\u201351 (2014).","journal-title":"J. Clin. Aesthet. 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E.","year":"1992","unstructured":"M. E. Stewart, Sebaceous gland lipids. Semin. Dermatol. 11, 100\u2013105 (1992).","journal-title":"Semin. Dermatol."},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030619"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/2031067b0"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1970.tb15759.x"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.049"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.2.8472"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0263"},{"key":"e_1_3_4_45_2","unstructured":"Z. Zhang Gene expression profile of sebaceous glands from male and female mice before and after sexual maturity. Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE308950. Deposited 23 September 2025."},{"key":"e_1_3_4_46_2","unstructured":"L. Zhang scRNA\u2011seq of enriched cells from mouse tail to elucidate the origin of sebocytes. Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE312971. Deposited 8 December 2025."},{"key":"e_1_3_4_47_2","unstructured":"L. Zhang scRNA\u2011seq of cells from preputial glands to elucidate the origin of sebocytes. Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE318555. Deposited 5 February 2026."},{"key":"e_1_3_4_48_2","unstructured":"L. Zhang Codes for the scRNA-seq analysis. GitHub. https:\/\/github.com\/lhzhanglabtools\/SG-analysis. Deposited 18 September 2025."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2615179123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:15:25Z","timestamp":1790961325000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2615179123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":48,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2026,10,6]]}},"alternative-id":["10.1073\/pnas.2615179123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2615179123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]},"assertion":[{"value":"2026-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2615179123"}}