{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:38:20Z","timestamp":1792604300323,"version":"4.5.0"},"reference-count":85,"publisher":"National Academy of Sciences","issue":"43","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011048","name":"Center for the Advancement of Science in Space","doi-asserted-by":"publisher","award":["CMMI: 2425684"],"award-info":[{"award-number":["CMMI: 2425684"]}],"id":[{"id":"10.13039\/100011048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000181","name":"DOW | AF | AMC | AFRL | Air Force Office of Scientific Research","doi-asserted-by":"publisher","award":["FA9550-24-1-0456"],"award-info":[{"award-number":["FA9550-24-1-0456"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"publisher","award":["Biohub"],"award-info":[{"award-number":["Biohub"]}],"id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008109","name":"University of Notre Dame","doi-asserted-by":"publisher","award":["Edison Innovation Fellowship"],"award-info":[{"award-number":["Edison Innovation Fellowship"]}],"id":[{"id":"10.13039\/100008109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001377","name":"Walther Cancer Foundation","doi-asserted-by":"publisher","award":["Interdisciplinary Interface Training Program Grant"],"award-info":[{"award-number":["Interdisciplinary Interface Training Program Grant"]}],"id":[{"id":"10.13039\/100001377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006370","name":"Small Business Innovation Research","doi-asserted-by":"publisher","award":["216101"],"award-info":[{"award-number":["216101"]}],"id":[{"id":"10.13039\/100006370","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Azenta","award":["Oncology Insights Grant Program"],"award-info":[{"award-number":["Oncology Insights Grant Program"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,10,27]]},"abstract":"<jats:p>Creating accurate organoid models remains a challenge, particularly for diseases like glioblastoma (GBM), an aggressive, treatment-resistant brain cancer with an immunosuppressive microenvironment. To overcome limitations of Earth-based models (sedimentation and disaggregation) and leverage the unique advantages of space (accelerated disease progression and immune dysregulation), this study utilizes a panel of GBM-myeloid organoids cultured for 40 d aboard the International Space Station. Spaceflight-grown GBM organoids have more uniform morphology compared to ground controls. We observed a context-dependent response to spaceflight, with the inclusion of macrophages and monocytes altering the bulk and spatial transcriptional response. While GBM-alone organoids have transcriptional markers of less aggressive disease in microgravity, organoids containing GBM cells + monocytes have increased expression of genes associated with disease progression and poor patient outcomes. Gene expression patterns are more spatially organized, with mesenchymal-related genes enriched in the core and inflammation-related genes enriched at the periphery, mimicking GBM tumor architecture. Microgravity-grown GBM+monocyte organoids exhibit increased secretion of proteins such as CXCL12 and LOX-1, associated with more aggressive disease. Infrared chemical imaging confirms spatial chemical gradients of DNA, protein, and lipid species in both space- and terrestrially-grown organoids. In summary, this work presents not only an advanced model of glioblastoma for basic and translational research but also demonstrates methods to acquire diverse data from organoids compatible with the unique constraints of in-space systems, helping establish a working model for orbital oncology.<\/jats:p>","DOI":"10.1073\/pnas.2616218123","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:44:30Z","timestamp":1792601070000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Multi-omics and spatial analysis of microgravity-grown glioblastoma organoids reveal superior modeling of advanced disease after long-term spaceflight"],"prefix":"10.1073","volume":"123","author":[{"given":"Alice","family":"Burchett Darantiere","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mkhxb43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Aerospace and Mechanical Engineering, University of Notre Dame","place":["Notre Dame"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-315X","authenticated-orcid":false,"given":"Maksym","family":"Zarodniuk","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mkhxb43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Aerospace and Mechanical Engineering, University of Notre Dame","place":["Notre Dame"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0772-8200","authenticated-orcid":false,"given":"Shelby","family":"Giza","sequence":"additional","affiliation":[{"name":"Space Tango, Limited Liability Company","place":["Lexington"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Rexroat","sequence":"additional","affiliation":[{"name":"Space Tango, Limited Liability Company","place":["Lexington"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8424-2400","authenticated-orcid":false,"given":"Paul","family":"Kuehl","sequence":"additional","affiliation":[{"name":"Space Tango, Limited Liability Company","place":["Lexington"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Twyman","family":"Clements","sequence":"additional","affiliation":[{"name":"Space Tango, Limited Liability Company","place":["Lexington"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthiveena","family":"Balraj","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/047426m28","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Bioengineering, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5242-760X","authenticated-orcid":false,"given":"Haley","family":"Marco","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mkhxb43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Aerospace and Mechanical Engineering, University of Notre Dame","place":["Notre Dame"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2147-1338","authenticated-orcid":false,"given":"Alura","family":"D\u2019Souza","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mkhxb43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Aerospace and Mechanical Engineering, University of Notre Dame","place":["Notre Dame"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5370-9924","authenticated-orcid":false,"given":"Julian","family":"Najera","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mkhxb43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Aerospace and Mechanical Engineering, University of Notre Dame","place":["Notre Dame"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-994X","authenticated-orcid":false,"given":"Rohit","family":"Bhargava","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/047426m28","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Bioengineering, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5727-8992","authenticated-orcid":false,"given":"Meenal","family":"Datta","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mkhxb43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Aerospace and Mechanical Engineering, University of Notre Dame","place":["Notre Dame"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-019-2742-0"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyae227"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262110664"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szae070"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-18440-6_9"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14460"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","unstructured":"A. M. A. Martins Dormant viral pathways underlie space-induced neural senescence. bioRxiv [Preprint] (2026). https:\/\/doi.org\/10.1101\/2025.11.02.686043v2 (Accessed 23 February 2026).","DOI":"10.1101\/2025.11.02.686043"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-026-01105-2"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214320"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2025.07.013"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2025.11.001"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau8650"},{"key":"e_1_3_4_13_2","unstructured":"Aspera Biomedicines Inc. \u201cA phase 1 study of Rebecsinib a spliceosome modulator that inhibits ADAR1 in patients with relapsed or refractory secondary acute myeloid leukemia or higher-risk myelofibrosis\u201d (Rep. no. NCT07250646 National Library of Medicine Bethesda MD 2026)."},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48916-8"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41526-023-00341-9"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","unstructured":"J. Li J. L. Ross D. Hambardzumyan D. J. Brat Immunopathology of glioblastoma. Annual Review of Pathology: Mechanisms of Disease 21 135\u2013162 (2026).","DOI":"10.1146\/annurev-pathmechdis-042524-025950"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-025-00920-x"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525349113"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_237987"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44385-026-00072-y"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49211-2"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-025-01226-6"},{"key":"e_1_3_4_23_2","first-page":"670","article-title":"The impact of microgravity on immunological states","volume":"7","author":"Hicks J.","year":"2023","unstructured":"J. Hicks, M. Olson, C. Mitchell, C. M. Juran, A. M. Paul, The impact of microgravity on immunological states. Immunohorizons 7, 670\u2013682 (2023).","journal-title":"Immunohorizons"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41526-021-00141-z"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2025.104503"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actaastro.2013.06.007"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep25975"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0346-6"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.03.029"},{"key":"e_1_3_4_30_2","unstructured":"S. A. Noggle V. Fossati D. Marotta J. Loring \u201cMethods and systems for culturing organoids.\u201d US Patent US20240417682A1 (2024)."},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-026-06881-5"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4BM00319E"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-024-00824-z"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.218216"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20785"},{"key":"e_1_3_4_36_2","first-page":"2140","article-title":"A bioinformatic study of IGFBPs in glioma regarding their diagnostic, prognostic, and therapeutic prediction value","volume":"15","author":"Liu H.","year":"2023","unstructured":"H. Liu, T. Tang, A bioinformatic study of IGFBPs in glioma regarding their diagnostic, prognostic, and therapeutic prediction value. Am. J. Transl. Res. 15, 2140\u20132155 (2023).","journal-title":"Am. J. Transl. Res."},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703145104"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells13030258"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.09.017"},{"key":"e_1_3_4_40_2","first-page":"369","article-title":"S100A8 promotes tumor progression by inducing phenotypic polarization of microglia through the TLR4\/IL-10 signaling pathway in glioma","volume":"4","author":"Yang Y.","year":"2024","unstructured":"Y. Yang , S100A8 promotes tumor progression by inducing phenotypic polarization of microglia through the TLR4\/IL-10 signaling pathway in glioma. J. Natl. Cancer Cent. 4, 369\u2013381 (2024).","journal-title":"J. Natl. Cancer Cent."},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00394-0"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-022-01069-3"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-025-02167-5"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.06.024"},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0254194","article-title":"Revealing immune responses in the Mycobacterium avium subsp. paratuberculosis-infected THP-1 cells using single cell RNA-sequencing","volume":"16","author":"Park H.-T.","year":"2021","unstructured":"H.-T. Park , Revealing immune responses in the Mycobacterium avium subsp. paratuberculosis-infected THP-1 cells using single cell RNA-sequencing. PLoS One 16, e0254194 (2021).","journal-title":"PLoS One"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1159\/000533130"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c07492"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now136"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-004-7327-y"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.17579"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2023.101739"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-020-00279-0"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01392-9"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13938"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3958069"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15325"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.02.005"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.123080"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-18440-6_8"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2024.119679"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-019-00334-7"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-017-0178-6"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.12.120"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.07.045"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov265"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.576382"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1173"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48625-2"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.110"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1910856117"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2026.1746344"},{"key":"e_1_3_4_72_2","unstructured":"T. L. Shaw J. M. Corliss D. P. Gundo G. M. Mulenburg \u201cSimulation of shuttle launch G Forces and acoustic loads using the NASA AMES research center 20G centrifuge\u201d (Rep. No: 95N14089 NASA Goddard Space Flight Center Eighteenth Space Simulation Conference: Space Mission Success Through Testing Greenbelt MD 1994)."},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1626024"},{"key":"e_1_3_4_74_2","first-page":"491","article-title":"Space radiation: The number one risk to astronaut health beyond low Earth orbit","volume":"4","author":"Chancellor J. C.","year":"2014","unstructured":"J. C. Chancellor, G. B. I. Scott, J. P. Sutton, Space radiation: The number one risk to astronaut health beyond low Earth orbit. Life (Basel) 4, 491\u2013510 (2014).","journal-title":"Life (Basel)"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84242-5"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81058-1"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radphyschem.2019.108373"},{"key":"e_1_3_4_78_2","first-page":"1091","article-title":"Cytoskeletal tensegrity in microgravity","volume":"11","author":"Gardiner J.","year":"2021","unstructured":"J. Gardiner, Cytoskeletal tensegrity in microgravity. Life (Basel) 11, 1091 (2021).","journal-title":"Life (Basel)"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.052077sc"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0273-1177(03)90399-1"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102402"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42013-y"},{"key":"e_1_3_4_83_2","unstructured":"M. Zarodniuk Microgravity GBM analyses. GitHub. https:\/\/github.com\/plezar\/microgravity-gbm. Deposited 8 October 2026."},{"key":"e_1_3_4_84_2","unstructured":"M. Zarodniuk Data from: \u201cMulti-omics and spatial analysis of microgravity-grown glioblastoma organoids reveals superior modeling of advanced disease after long-term spaceflight.\u201d NCBI Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE345072. Deposited 26 August 2026."},{"key":"e_1_3_4_85_2","doi-asserted-by":"crossref","unstructured":"A. Burchett Darantiere Data from: \u201cMulti-omics and spatial analysis of microgravity-grown glioblastoma organoids reveals superior modeling of advanced disease after long-term spaceflight.\u201d NCBI Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE344569. Deposited 20 August 2026.","DOI":"10.64898\/2026.03.06.710192"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2616218123","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2616218123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:45:20Z","timestamp":1792601120000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2616218123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":85,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2026,10,27]]}},"alternative-id":["10.1073\/pnas.2616218123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2616218123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"assertion":[{"value":"2026-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2616218123"}}