{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:18:18Z","timestamp":1788286698709,"version":"build-2803163510"},"reference-count":7,"publisher":"National Academy of Sciences","issue":"36","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013465","name":"French Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["17385"],"award-info":[{"award-number":["17385"]}],"id":[{"id":"10.13039\/100013465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FDT201904007903"],"award-info":[{"award-number":["FDT201904007903"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:p>\n                    The spatial organization of the genome within the nucleus is critical for gene regulation, yet the mechanisms by which transcription factors (TFs) orchestrate this process remain poorly understood. Here, we demonstrate that the\n                    <jats:italic toggle=\"yes\">Drosophila<\/jats:italic>\n                    Hox protein Ultrabithorax (Ubx) represses autophagy-related (\n                    <jats:italic toggle=\"yes\">atg<\/jats:italic>\n                    ) genes by tethering their loci to the nuclear periphery. This repressive activity relies on the interaction with the nuclear lamina component Lamin-C (LamC). Furthermore, we identify that DNA-binding of Ubx is determinant for both the physical interaction with nucleoplasmic LamC and the repression of\n                    <jats:italic toggle=\"yes\">atg<\/jats:italic>\n                    genes in vivo. Together, our findings reveal a mechanism whereby a Hox TF functions as a spatial anchor, positioning target genes within a LamC-rich nuclear compartment to ensure efficient transcriptional repression.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2616645123","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:58:11Z","timestamp":1788285491000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["A Hox-dependent anchoring mechanism mediates transcriptional repression of autophagy-related genes at the nuclear periphery"],"prefix":"10.1073","volume":"123","author":[{"given":"Sol\u00e8ne","family":"Vanderperre","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zmssz18","id-type":"ROR","asserted-by":"publisher"}],"name":"Institut de G\u00e9nomique Fonctionnelle de Lyon, CNRS UMR5242, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Lyon-I","place":["Lyon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5375-3370","authenticated-orcid":false,"given":"Leiore","family":"Ajuria","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zmssz18","id-type":"ROR","asserted-by":"publisher"}],"name":"Institut de G\u00e9nomique Fonctionnelle de Lyon, CNRS UMR5242, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Lyon-I","place":["Lyon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-2865","authenticated-orcid":false,"given":"Marilyne","family":"Duffraisse","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zmssz18","id-type":"ROR","asserted-by":"publisher"}],"name":"Institut de G\u00e9nomique Fonctionnelle de Lyon, CNRS UMR5242, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Lyon-I","place":["Lyon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3128-3943","authenticated-orcid":false,"given":"Tristan","family":"Da Silva","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zmssz18","id-type":"ROR","asserted-by":"publisher"}],"name":"Institut de G\u00e9nomique Fonctionnelle de Lyon, CNRS UMR5242, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Lyon-I","place":["Lyon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0828-8137","authenticated-orcid":false,"given":"Samantha","family":"Vonau","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zmssz18","id-type":"ROR","asserted-by":"publisher"}],"name":"Institut de G\u00e9nomique Fonctionnelle de Lyon, CNRS UMR5242, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Lyon-I","place":["Lyon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0752-5737","authenticated-orcid":false,"given":"Jacques","family":"Brocard","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zmssz18","id-type":"ROR","asserted-by":"publisher"}],"name":"Plateau d\u2019imagerie et de microscopie, Universit\u00e9 Lyon 1, CNRS-UAR3444, INSERM-US8, \u00c9cole Normale Sup\u00e9rieure de Lyon","place":["Lyon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2482-0391","authenticated-orcid":false,"given":"Christelle","family":"Forcet","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zmssz18","id-type":"ROR","asserted-by":"publisher"}],"name":"Institut de G\u00e9nomique Fonctionnelle de Lyon, CNRS UMR5242, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Lyon-I","place":["Lyon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7629-703X","authenticated-orcid":false,"given":"Samir","family":"Merabet","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zmssz18","id-type":"ROR","asserted-by":"publisher"}],"name":"Institut de G\u00e9nomique Fonctionnelle de Lyon, CNRS UMR5242, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Lyon-I","place":["Lyon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.109785"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.11.024"},{"key":"e_1_3_3_3_2","first-page":"133","article-title":"Role of a versatile peptide motif controlling Hox nuclear export and autophagy in the Drosophila fat body","volume":"23","author":"Duffraisse M.","year":"2020","unstructured":"M. Duffraisse , Role of a versatile peptide motif controlling Hox nuclear export and autophagy in the Drosophila fat body. J. Cell Sci. 23, 133 (2020).","journal-title":"J. Cell Sci."},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","unstructured":"R.-U.-S. Hemba-Waduge Adipocyte heterogeneity regulated by the Bithorax Complex-Wnt signaling crosstalk in Drosophila. EMBO Rep. 27 367\u2013386 (2026).","DOI":"10.1038\/s44319-025-00625-z"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00587"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.021"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115771"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2616645123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:58:27Z","timestamp":1788285507000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2616645123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":7,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2026,9,8]]}},"alternative-id":["10.1073\/pnas.2616645123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2616645123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2026-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2616645123"}}