{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:51:41Z","timestamp":1791312701997,"version":"4.3.1"},"reference-count":77,"publisher":"National Academy of Sciences","issue":"41","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IOS-2048410"],"award-info":[{"award-number":["IOS-2048410"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM121445"],"award-info":[{"award-number":["R01GM121445"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:p>\n                    Extracellular Adenosine 5\u2032-triphosphate (eATP) is a damage-associated molecular pattern in both plants and animals, playing an important role as a danger signal in response to various environmental stresses. eATP works both independently and in coordination with other signaling pathways. Here, we identify a previously uncharacterized\n                    <jats:underline>p<\/jats:underline>\n                    roline-rich\n                    <jats:underline>e<\/jats:underline>\n                    xtensin-like\n                    <jats:underline>r<\/jats:underline>\n                    eceptor\n                    <jats:underline>k<\/jats:underline>\n                    inase 15 (PERK15), which interacts with the plant eATP receptor P2K1 and integrates eATP and salicylic acid (SA)-mediated pathogen defense responses.\n                    <jats:italic toggle=\"yes\">perk15<\/jats:italic>\n                    mutant plants display reduced eATP responses and compromised pathogen resistance, whereas ectopic overexpression of\n                    <jats:italic toggle=\"yes\">PERK15<\/jats:italic>\n                    triggers autoimmunity. eATP treatment enhances PERK15\u2013P2K1 interaction. P2K1-mediated phosphorylation of a Ser\/Thr cluster in the PERK15 kinase domain is essential for its activation.\n                    <jats:italic toggle=\"yes\">PERK15<\/jats:italic>\n                    transcript levels are upregulated by SA, and\n                    <jats:italic toggle=\"yes\">PERK15<\/jats:italic>\n                    overexpression promotes the protein accumulation of the SA receptor NPR1. Data show that eATP and SA act synergistically to regulate plant defense responses in a PERK15-dependent manner. Together, the findings identify PERK15 as a key node linking eATP and SA signaling, providing insights into how plants integrate extracellular danger signals and defense hormone signals to mount effective immune responses.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2616716123","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:04:38Z","timestamp":1791309878000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["A receptor-like kinase pair integrates extracellular ATP and salicylic acid signaling to activate plant immunity"],"prefix":"10.1073","volume":"123","author":[{"given":"Mengran","family":"Yang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02ymw8z06","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Plant Science and Technology, Christopher S. 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Yang G. Stacey Data from \u201cRNA-sequencing of eATP and SA co-treated Arabidopsis plants.\u201d NCBI BioProject. https:\/\/www.ncbi.nlm.nih.gov\/bioproject\/PRJNA1454510. Deposited 16 April 2026."},{"key":"e_1_3_4_77_2","unstructured":"M. Yang Data from \u201cA receptor-like kinase pair integrates extracellular ATP and salicylic acid signaling to activate plant immunity.\u201d PRIDE. https:\/\/www.ebi.ac.uk\/pride\/archive\/projects\/PXD077905. 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