{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:49:44Z","timestamp":1788493784669,"version":"build-2803163510"},"reference-count":33,"publisher":"National Academy of Sciences","issue":"29","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401708"],"award-info":[{"award-number":["82401708"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"JST | Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20240788"],"award-info":[{"award-number":["BK20240788"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100023885","name":"HHS | NIH | All of Us Research Program","doi-asserted-by":"publisher","award":["R01MH117139"],"award-info":[{"award-number":["R01MH117139"]}],"id":[{"id":"10.13039\/100023885","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,7,21]]},"abstract":"<jats:p>Excitatory glutamatergic synapses in the brain are remarkably plastic. Two forms of plasticity have received the most attention: long-term potentiation (LTP) and synaptic homeostasis. While LTP requires the activation of NMDA receptors, synaptic homeostasis does not. However, both phenomena are mediated by the recruitment of postsynaptic AMPA receptors (AMPAR) to the synapse. Recently a new form of plasticity has been described referred to as presynaptic homeostatic plasticity (PHP). Pharmacological inhibition of AMPAR synaptic responses in CA1 hippocampal pyramidal cells initiates a rapid homeostatic response that results in the recovery of the AMPAR responses to normal values in the continued presence of the inhibitor. Accompanying this recovery is a doubling of the NMDA receptor response which is interpreted as an increase in the release of glutamate. This is provocative since claiming that a reduction in AMPAR responses triggers an enhancement in NMDA receptor responses. Using three different protocols to monitor synaptic responses we fail to observe any recovery of synaptic responses in the presence of an AMPAR inhibitor. Furthermore, there was no enhancement in NMDA receptor responses. Thus, we find no evidence for the presence of PHP at CA1 hippocampal synapses.<\/jats:p>","DOI":"10.1073\/pnas.2617982123","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:17:56Z","timestamp":1784045876000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["A reassessment of NMDA receptor\u2013dependent presynaptic homeostatic plasticity"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5764-6705","authenticated-orcid":false,"given":"Xiumin","family":"Chen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02xjrkt08","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurology and Clinical Research Center of Neurological Diseases, The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]},{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Institute of Neuroscience, Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianli","family":"Dou","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Institute of Neuroscience, Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Institute of Neuroscience, Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Hong","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Institute of Neuroscience, Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Nicoll","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cellular and Molecular Pharmacology, University of California","place":["San Franscico"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.12.015"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.10.018"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.25.112701.142758"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.008"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1716022114"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.08.014"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2025.05.030"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1707472114"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.02.027"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23024"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60360"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.012"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4733-03.2004"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.05.016"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111483"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1551"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-14-06027.1999"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/35050030"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04439-7"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","unstructured":"P. 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