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In lean and diet-induced obese mice, weekly\n                    <jats:italic toggle=\"yes\">Zfp423<\/jats:italic>\n                    ASO treatment induced white adipose beiging, increased body temperature and oxygen consumption, and improved glucose homeostasis, insulin sensitivity, lipid metabolism, mitochondrial respiration, and hepatic steatosis. When combined with the GLP1-RA semaglutide,\n                    <jats:italic toggle=\"yes\">Zfp423<\/jats:italic>\n                    ASO produced greater weight and fat loss than either monotherapy while preserving lean mass and improving metabolic outcomes. These findings identify\n                    <jats:italic toggle=\"yes\">Zfp423<\/jats:italic>\n                    as an RNA therapeutic target and support adipose thermogenesis as a complementary strategy for metabolically healthier obesity treatment.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2618845123","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:34:42Z","timestamp":1790350482000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["An RNA thermogenic therapy to preserve lean mass and enhance metabolic health during GLP-1 weight loss"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5069-6497","authenticated-orcid":false,"given":"Anneke K.","family":"Thorne","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern 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