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During our investigation of\n                    <jats:italic toggle=\"yes\">Streptococcus<\/jats:italic>\n                    <jats:italic toggle=\"yes\">mitis<\/jats:italic>\n                    , an important early colonizer of the oral cavity, we identified and structurally characterized a family of peptide natural products, termed miranthins herein, that contain an unusual macrocycle formed by an Asp-Cys \u03b2-carbon thioether crosslink. We determined that the most abundantly secreted miranthin is a \u201cTrojan horse\u201d antibiotic that enters sensitive cells via the Ami oligopeptide transporter, is hydrolyzed and activated by aminopeptidase N, and subsequently inhibits ribosomal translation to curb the growth of streptococcal competitors. The miranthins are narrow-spectrum antibiotics that could enable\n                    <jats:italic toggle=\"yes\">S. mitis<\/jats:italic>\n                    to modulate community dynamics in the oral cavity, highlighting the importance of peptide natural products in interspecies competition in the microbiome.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2621138123","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:03:09Z","timestamp":1791831789000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Discovery and characterization of miranthins, \u201cTrojan horse\u201d antibiotic modulators of bacterial composition in the oral microbiome"],"prefix":"10.1073","volume":"123","author":[{"given":"Brielle E.","family":"Dalvano","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hx57361","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Biology, Princeton University","place":["Princeton"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett C.","family":"Covington","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hx57361","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Chemistry, Princeton University","place":["Princeton"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2707-4854","authenticated-orcid":false,"given":"Mohammad R.","family":"Seyedsayamdost","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hx57361","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Biology, Princeton University","place":["Princeton"]},{"id":[{"id":"https:\/\/ror.org\/00hx57361","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Chemistry, Princeton University","place":["Princeton"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11234"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature23889"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.11.5721-5732.2005"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46923-0"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31502-1"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1177486"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00974-4"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/np50066a001"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-44964-7_1"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.08.032"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00321-19"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1086"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58280-w"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254766"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV119.006545"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2011.05.001"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw9969"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.009416"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.59.9.2876-2883.1993"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2004045117"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063253"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.59.7.2014-2021.1993"},{"key":"e_1_3_4_23_2","first-page":"19","article-title":"The ecology of bacteriocin-producing strains of Streptococcus salivarius","volume":"2","author":"Tompkins G. 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