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Our findings establish that SAH acts as a metabolic signal coupling nutrient and energy availability to longevity via Ybt1, defining an adaptive\/hormetic response for lifespan regulation in yeast.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2621286123","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:39:04Z","timestamp":1792172344000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["<i>S<\/i>\n                    -adenosyl-L-homocysteine triggers an adaptive response that extends lifespan through the\n                    <i>YBT1<\/i>\n                    ABC transporter"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6742-0809","authenticated-orcid":false,"given":"Koji","family":"Masumura","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03t78wx29","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of 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