{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:38:23Z","timestamp":1791830303928,"version":"4.3.4"},"reference-count":43,"publisher":"National Academy of Sciences","issue":"40","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | NIH","doi-asserted-by":"publisher","award":["1R35GM148173"],"award-info":[{"award-number":["1R35GM148173"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:p>\n                    Peptide hormone signaling coordinates plant growth and osmotic stress responses, yet how the transition between these responses is regulated remains poorly understood. Here, we investigated the function of the rice PLANT PEPTIDES CONTAINING SULFATED TYROSINE 8 (OsPSY8) peptide in osmotic stress responses.\n                    <jats:italic toggle=\"yes\">OsPSY8<\/jats:italic>\n                    was predominantly expressed in root tissues under nonstress conditions, with preferential expression in lateral roots where it promoted root growth. Osmotic stress rapidly reduced\n                    <jats:italic toggle=\"yes\">OsPSY8<\/jats:italic>\n                    expression in roots through the OsWRKY24 transcription factor. Loss-of-function\n                    <jats:italic toggle=\"yes\">ospsy8<\/jats:italic>\n                    mutants exhibited enhanced osmotic stress tolerance, whereas\n                    <jats:italic toggle=\"yes\">OsPSY8<\/jats:italic>\n                    overexpression increased osmotic stress susceptibility. Transcriptomic analyses revealed that disruption of\n                    <jats:italic toggle=\"yes\">OsPSY8<\/jats:italic>\n                    activated stress-responsive pathways, including those associated with lignin biosynthesis, compatible solute production, cell wall remodeling, and reactive oxygen species scavenging, and was accompanied by increased lignin accumulation in roots. In contrast, overexpression of\n                    <jats:italic toggle=\"yes\">OsPSY8<\/jats:italic>\n                    resulted in maintenance of growth-associated transcriptional programs while suppressing stress-responsive pathways under osmotic stress. Together, these findings identify OsPSY8 as an important regulator of the transition from growth to stress adaptation in rice and suggest that stress-induced repression of PSY signaling is required to disengage growth programs and activate adaptive responses during osmotic stress.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2622107123","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:09:36Z","timestamp":1790870976000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["Signaling by a tyrosine-sulfated peptide balances growth and osmotic stress response in rice"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1464-2760","authenticated-orcid":false,"given":"Yejin","family":"Shim","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Plant Pathology, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen Y.","family":"Rim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00f54p054","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Chemical Engineering","place":["Stanford University"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin C.-Y.","family":"Liao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Plant Pathology, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7638-7235","authenticated-orcid":false,"given":"Myeong-Je","family":"Cho","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01an7q238","id-type":"ROR","asserted-by":"publisher"}],"name":"Innovative Genomics Institute, University of California","place":["Berkeley"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Austin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01an7q238","id-type":"ROR","asserted-by":"publisher"}],"name":"Innovative Genomics Institute, University of California","place":["Berkeley"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Carlos","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0384j8v12","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Chemistry, The University of Sydney","place":["Sydney, NSW, Australia"]},{"id":[{"id":"https:\/\/ror.org\/0384j8v12","id-type":"ROR","asserted-by":"publisher"}],"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney","place":["Sydney, NSW, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer S.","family":"Kulkarni","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0384j8v12","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Chemistry, The University of Sydney","place":["Sydney, NSW, Australia"]},{"id":[{"id":"https:\/\/ror.org\/0384j8v12","id-type":"ROR","asserted-by":"publisher"}],"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney","place":["Sydney, NSW, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3618-9226","authenticated-orcid":false,"given":"Richard J.","family":"Payne","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0384j8v12","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Chemistry, The University of Sydney","place":["Sydney, NSW, Australia"]},{"id":[{"id":"https:\/\/ror.org\/0384j8v12","id-type":"ROR","asserted-by":"publisher"}],"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney","place":["Sydney, NSW, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Florencia","family":"Ercoli","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Plant Pathology, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4107-1345","authenticated-orcid":false,"given":"Pamela C.","family":"Ronald","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Plant Pathology, University of California","place":["Davis"]},{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"The Genome Center, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2025.1547452"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-97550-x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/nph.16241"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2024.100918"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/bse0580115"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0009-2"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-66392-6"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57291-x"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz5641"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706403104"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/nph.14609"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-68640-9"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41477-026-02301-z"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq5735"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stress.2024.100412"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rsci.2017.04.004"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41477-022-01118-w"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2021.08.018"},{"key":"e_1_3_4_19_2","first-page":"D1104","article-title":"PlantRegMap: Charting functional regulatory maps in plants","volume":"48","author":"Tian F.","year":"2020","unstructured":"F. 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Shim P. Ronald Root transcriptomes of rice OsPSY8 overexpression and knockout lines following polyethylene glycol-induced osmotic stress. Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE347843. Deposited 18 September 2026."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2622107123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:10:12Z","timestamp":1790871012000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2622107123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":43,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2026,10,6]]}},"alternative-id":["10.1073\/pnas.2622107123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2622107123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"2026-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2622107123"}}