{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:58:59Z","timestamp":1791392339839,"version":"4.3.3"},"reference-count":16,"publisher":"National Academy of Sciences","issue":"41","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Norwegian Research Council","award":["234817"],"award-info":[{"award-number":["234817"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:p>\n                    Sensory systems, built around specialized cell types, are central to how animals perceive and respond to their environments. However, the evolutionary origin of these systems remains unclear. Here, we show that choanoflagellates, the sister group of animals, possess remarkably diverse repertoires of transient receptor potential (TRP) channels, an ancient superfamily of sensory ion channels. Comparative analyses indicate that most major animal TRP channel families predate the origin of animals and reveal extensive radiations of the TRPM and TRPW families within choanoflagellates, with the latter family likely being lost in the animal lineage. Furthermore, in the choanoflagellate model\n                    <jats:italic toggle=\"yes\">Salpingoeca rosetta<\/jats:italic>\n                    , TRPA, TRPC and TRPV occupy discrete microdomains within the collar complex, a key interface for environmental sensing and feeding. We propose that the evolution of animal sensory systems involved both expansion and reorganization of this ancestral repertoire, with subcellular patterning in unicellular organisms representing a precursor to cell-type specialization in multicellular animals.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2625484123","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:35:51Z","timestamp":1791390951000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Diversity and spatial segregation of TRP channels in the closest relatives of animals"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5723-6064","authenticated-orcid":false,"given":"Simen","family":"Manns\u00e5ker","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03zga2b32","id-type":"ROR","asserted-by":"publisher"}],"name":"Michael Sars Centre, University of Bergen","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9826-057X","authenticated-orcid":false,"given":"Pawel","family":"Burkhardt","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03zga2b32","id-type":"ROR","asserted-by":"publisher"}],"name":"Michael Sars Centre, University of Bergen","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3912-0926","authenticated-orcid":false,"given":"Jeffrey","family":"Colgren","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03zga2b32","id-type":"ROR","asserted-by":"publisher"}],"name":"Michael Sars Centre, University of Bergen","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-025-00983-6"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-120123-112853"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10071-023-01776-z"},{"key":"e_1_3_3_4_2","first-page":"20201309","article-title":"Transient receptor potential channels: Current perspectives on evolution, structure, function and nomenclature","volume":"2020","author":"Himmel N. J.","year":"1933","unstructured":"N. J. Himmel, D. N. Cox, Transient receptor potential channels: Current perspectives on evolution, structure, function and nomenclature. Proc. Biol. Sci. 2020, 20201309 (1933).","journal-title":"Proc. Biol. Sci."},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","unstructured":"B. S. Leadbeater The Choanoflagellates (Cambridge University Press UK 2015).","DOI":"10.1017\/CBO9781139051125"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.107467"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst241"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.06.003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adr7434"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-66641-8"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2014.06.016"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-2-r15"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26036"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06608-5"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E18-08-0514"},{"key":"e_1_3_3_16_2","unstructured":"J. Colgren S. Mannsaker P. Burkhardt Data and code from: Diversity and spatial segregation of TRP channels in the closest relatives of animals [Dataset]. Dryad. https:\/\/datadryad.org\/dataset\/doi:10.5061\/dryad.d7wm37qh8. Deposited 17 September 2026."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2625484123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:36:30Z","timestamp":1791390990000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2625484123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":16,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2026,10,13]]}},"alternative-id":["10.1073\/pnas.2625484123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2625484123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2026-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2625484123"}}