{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:56:11Z","timestamp":1792173371459,"version":"4.4.0"},"reference-count":104,"publisher":"National Academy of Sciences","issue":"42","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"MEC | Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PDC2022-133344-I00 PID2022-137827OB-I00 and PID2025-171123OB-I00"],"award-info":[{"award-number":["PDC2022-133344-I00 PID2022-137827OB-I00 and PID2025-171123OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"MEC | Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["RYC2020-029773-I PID2021-128682OA-I00"],"award-info":[{"award-number":["RYC2020-029773-I PID2021-128682OA-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"MEC | Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PRE2020-096731"],"award-info":[{"award-number":["PRE2020-096731"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Government of Catalonia | Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2021SGR00423"],"award-info":[{"award-number":["2021SGR00423"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["EquipEx+ France Cryo-EM project (ANR-21-ESRE-0046)."],"award-info":[{"award-number":["EquipEx+ France Cryo-EM project (ANR-21-ESRE-0046)."]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instruct + ERIC","award":["PID43623"],"award-info":[{"award-number":["PID43623"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:p>\n                    Human immunoglobulin (Ig) A (IgA) protects \u2248400 m\n                    <jats:sup>2<\/jats:sup>\n                    of mucosae from microbes. Bacterial IgA-peptidases subvert this defense by cleaving the F\n                    <jats:sub>ab<\/jats:sub>\n                    \u2013F\n                    <jats:sub>c<\/jats:sub>\n                    hinge of subclass IgA1 while sparing the hinge-divergent, colon-dominant IgA2 subclass. The exception is IgAse, a \u2248140-kDa, seven-domain, membrane-bound metallopeptidase from the colonic commensal\n                    <jats:italic toggle=\"yes\">Thomasclavelia ramosa<\/jats:italic>\n                    that targets both subclasses but no other protein. We previously narrowed the minimal functional assembly down to the IgAse catalytic and wrapping domains (CD and WD) plus the IgA1\/2 F\n                    <jats:sub>ab<\/jats:sub>\n                    \u2032, i.e., the hinge and a F\n                    <jats:sub>ab<\/jats:sub>\n                    of light and heavy chains (LC, HC), each with a variable and a constant Ig domain (V\n                    <jats:sub>L<\/jats:sub>\n                    + C\n                    <jats:sub>L<\/jats:sub>\n                    , V\n                    <jats:sub>H<\/jats:sub>\n                    + C\n                    <jats:sub>H<\/jats:sub>\n                    1). The transient interaction culminates in cleavage of a proline\u2013valine bond within the first two hinge residues, downstream of a conserved C-terminal C\n                    <jats:sub>H<\/jats:sub>\n                    1 disulfide (SS2). Here, single-particle cryoelectron microscopy of a disulfide-stabilized minimal IgAse:IgA2 F\n                    <jats:sub>ab<\/jats:sub>\n                    \u2032 complex yielded high-quality density strongly supporting two states along the cleavage reaction coordinate, a \u201crecognition complex\u201d and a subsequent \u201cprecatalytic complex,\u201d in which F\n                    <jats:sub>ab<\/jats:sub>\n                    \u2032 binds frontally to the IgAse CD via a C\n                    <jats:sub>H<\/jats:sub>\n                    1 \u03b2-sheet and overhang loop L\u03b2E\u03b2F. This loop binds like a knob to a preformed hole in the active-site cleft. Binding rearranges the knob and rotates SS2 \u2248 180\u00b0, enabling access of the hinge into the cleft of the otherwise unaffected precatalytic complex. Together, this work defines a unique, C\n                    <jats:sub>H<\/jats:sub>\n                    1-mediated hinge-delivering \u201cgate\u201d mechanism, validated by a crystal structure of unbound IgA2 F\n                    <jats:sub>ab<\/jats:sub>\n                    , point mutations disrupting the C\n                    <jats:sub>H<\/jats:sub>\n                    1:CD interface, and molecular dynamics calculations, which provide the structural framework for subclass-independent IgA cleavage.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2626241123","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:39:04Z","timestamp":1792172344000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["A \u201cknob-in-hole\u201d gate in the antibody C\n                    <sub>H<\/sub>\n                    1 domain underlies subclass-independent IgA hinge cleavage by the commensal metallopeptidase IgAse"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2887-209X","authenticated-orcid":false,"given":"Juan","family":"Sebasti\u00e1n Ram\u00edrez-Larrota","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02gfc7t72","id-type":"ROR","asserted-by":"publisher"}],"name":"Proteolysis Laboratory, Department of Structural Biology, Molecular Biology Institute of Barcelona (Consejo Superior de Investigaciones Cient\u00edficas)","place":["Barcelona, Spain"]},{"id":[{"id":"https:\/\/ror.org\/02gfc7t72","id-type":"ROR","asserted-by":"publisher"}],"name":"Synthetic Structural Biology Group, Department of Structural Biology, Molecular Biology Institute of Barcelona (Consejo Superior de Investigaciones Cient\u00edficas)","place":["Barcelona, Spain"]},{"id":[{"id":"https:\/\/ror.org\/021018s57","id-type":"ROR","asserted-by":"publisher"}],"name":"Graduate Program in Biotechnology, Faculty of Pharmacy and Food Sciences, University of Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9190-0211","authenticated-orcid":false,"given":"Guillem Arasa","family":"Estivill","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02gfc7t72","id-type":"ROR","asserted-by":"publisher"}],"name":"Synthetic Structural Biology Group, Department of Structural Biology, Molecular Biology Institute of Barcelona (Consejo Superior de Investigaciones Cient\u00edficas)","place":["Barcelona, Spain"]},{"id":[{"id":"https:\/\/ror.org\/021018s57","id-type":"ROR","asserted-by":"publisher"}],"name":"Graduate Program in Biotechnology, Faculty of Pharmacy and Food Sciences, University of Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5496-9827","authenticated-orcid":false,"given":"Mario","family":"L\u00f3pez-Mart\u00edn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02gfc7t72","id-type":"ROR","asserted-by":"publisher"}],"name":"Synthetic Structural Biology Group, Department of Structural Biology, Molecular Biology Institute of Barcelona (Consejo Superior de Investigaciones Cient\u00edficas)","place":["Barcelona, Spain"]},{"id":[{"id":"https:\/\/ror.org\/02gfc7t72","id-type":"ROR","asserted-by":"publisher"}],"name":"Protein Design and Modelling, Department of Structural Biology, Molecular Biology Institute of Barcelona (Consejo Superior de Investigaciones Cientificas)","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6957-0875","authenticated-orcid":false,"given":"Gregory","family":"Effantin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03949e763","id-type":"ROR","asserted-by":"publisher"}],"name":"Methods and Electron Microscopy Group, University Grenoble-Alpes, Centre National de la Recherche Scientifique, Commissariat \u00e0 l\u2019\u00c9nergie Atomique, European Molecular Biology Laboratory, Integrated Structural Biology Grenoble","place":["Grenoble, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-1743","authenticated-orcid":false,"given":"Marcos","family":"Gragera","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02gfc7t72","id-type":"ROR","asserted-by":"publisher"}],"name":"Biocomputing Unit, Centro Nacional de Biotecnolog\u00eda (Consejo Superior de Investigaciones Cientificas), Campus Universidad Aut\u00f3noma","place":["Cantoblanco, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos \u00d3scar S\u00e1nchez","family":"Sorzano","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02gfc7t72","id-type":"ROR","asserted-by":"publisher"}],"name":"Biocomputing Unit, Centro Nacional de Biotecnolog\u00eda (Consejo Superior de Investigaciones Cientificas), Campus Universidad Aut\u00f3noma","place":["Cantoblanco, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8736-4082","authenticated-orcid":false,"given":"Enrique","family":"Marcos","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02gfc7t72","id-type":"ROR","asserted-by":"publisher"}],"name":"Protein Design and Modelling, Department of Structural Biology, Molecular Biology Institute of Barcelona (Consejo Superior de Investigaciones Cientificas)","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5863-4514","authenticated-orcid":false,"given":"Ulrich","family":"Eckhard","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02gfc7t72","id-type":"ROR","asserted-by":"publisher"}],"name":"Synthetic Structural Biology Group, Department of Structural Biology, Molecular Biology Institute of Barcelona (Consejo Superior de Investigaciones Cient\u00edficas)","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6848-6874","authenticated-orcid":false,"given":"Francesc Xavier","family":"Gomis-R\u00fcth","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02gfc7t72","id-type":"ROR","asserted-by":"publisher"}],"name":"Proteolysis Laboratory, Department of Structural Biology, Molecular Biology Institute of Barcelona (Consejo Superior de Investigaciones Cient\u00edficas)","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00553"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.898326"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.013"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2025.101984"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/antib8040057"},{"key":"e_1_3_4_6_2","first-page":"55","volume-title":"Clinical Immunology\u2014Principles and Practice","author":"Schroeder H. W.","year":"2023","unstructured":"H. W. Schroeder Jr., L. Gapin, R. M. Torres, \u201cPart I. Chapter 4 \u2014 Antigen receptor genes, gene products, and co-receptors.\u201d in Clinical Immunology\u2014Principles and Practice, R. R. Rich , Eds. (Elsevier, India, 2023), pp. 55\u201377. 10.1016\/B978-0-7020-8165-1.00004-6."},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2611543"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070131"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.03.007"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.2.966"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.5072"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.3.1104"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.O116.058503"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-28849-4.00067-9"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1013292"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44318-025-00518-w"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.134.1.573"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.111.4.1274"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.113.1.289"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3948"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)01079-X"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.005694"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-28849-4.00232-0"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(67)80055-X"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2011.04.014"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110883200"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2503549122"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-04173-3"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.04.041"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2400"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00030"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06522"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001193"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63766-8"},{"key":"e_1_3_4_35_2","first-page":"864","volume-title":"Biochemistry: The Molecular Basis of Life","author":"McKee T.","year":"2008","unstructured":"T. McKee, J. R. McKee, Biochemistry: The Molecular Basis of Life (Oxford University Press, New York, ed. 4, 2008), pp. 864.","edition":"4"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2023.102519"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02163-3"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0022-2836(84)71582-8","article-title":"The immunoglobulin fold. Structural classification, sequence patterns and common core","volume":"242","author":"Bork P.","year":"1994","unstructured":"P. Bork, L. Holm, C. Sander, The immunoglobulin fold. Structural classification, sequence patterns and common core. J. Mol. Biol. 242, 309\u2013320 (1994).","journal-title":"J. Mol. Biol."},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1012813"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.05.022"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1994.1312"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2023.11.002"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.01.023"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19887-3"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz5807"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35340-z"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708481200"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.7b00121"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444912048664"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abg2344"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(85)90148-8"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612567"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.060003969.x"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.1"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-382219-2.00279-9"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015080856"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-021-00874-9"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164630"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.08.006"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep05885"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku893"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112643"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4169"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0575-8"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2016.04.010"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2012.09.006"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-024-02304-8"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02399-1"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-023-01874-3"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4792"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798318009324"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798319011471"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2003.07.013"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3791"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798318006551"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909047337"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909047374"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"e_1_3_4_80_2","unstructured":"R. L. Dunbrack Jr. R\u0113s ipSAE loquunt: What\u2019s wrong with AlphaFold\u2019s ipTM score and how to fix it. bioRxiv [Preprint] (2025). 10.1101\/2025.02.10.637595 (Accessed 20 July 2026)."},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20264"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-025-01189-x"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01585-1"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp505875v"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm276"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00255"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5c01063"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(04)03363-X"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904026460"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0567739476001873"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798323003595"},{"key":"e_1_3_4_92_2","first-page":"5998","volume-title":"Advances in Neural Information Processing Systems","author":"Vaswani A.","year":"2017","unstructured":"A. Vaswani , \u201cAttention is all you need\u201d in Advances in Neural Information Processing Systems, I. Guyon , Eds. (Curran Associates Inc, Red Hook, N.Y., 2017), vol. 30, pp. 5998\u20136008."},{"key":"e_1_3_4_93_2","doi-asserted-by":"crossref","unstructured":"J. S. Ram\u00edrez-Larrota U. Eckhard F. X. Gomis-R\u00fcth Crystal structure of the Human IgA2 Fab fragment. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/31VY. Deposited 25 June 2026.","DOI":"10.2210\/pdb31vy\/pdb"},{"key":"e_1_3_4_94_2","unstructured":"J. S. Ram\u00edrez-Larrota U. Eckhard F. X. Gomis-R\u00fcth Cryo-EM structure of the IgAseDS1\u2020:Fab\u2032DS1 precatalytic complex. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/31XJ. Deposited 26 June 2026."},{"key":"e_1_3_4_95_2","unstructured":"J. S. Ram\u00edrez-Larrota U. Eckhard F. X. Gomis-R\u00fcth Cryo-EM structure of the IgAseDS1\u2020:Fab\u2032DS1 recognition complex. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/31YN. Deposited 29 June 2026."},{"key":"e_1_3_4_96_2","unstructured":"J. S. Ram\u00edrez-Larrota M. Gragera U. Eckhard F. X. Gomis-R\u00fcth Cryo-EM map 1 for the IgAseDS1\u2020:Fab\u2032DS1 precatalytic complex. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-58685. Deposited 4 August 2026."},{"key":"e_1_3_4_97_2","unstructured":"J. S. Ram\u00edrez-Larrota M. Gragera U. Eckhard F. X. Gomis-R\u00fcth Cryo-EM map 2 for the IgAseDS1\u2020:Fab\u2032DS1 precatalytic complex. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-58686. Deposited 4 August 2026."},{"key":"e_1_3_4_98_2","unstructured":"J. S. Ram\u00edrez-Larrota M. Gragera U. Eckhard F. X. Gomis-R\u00fcth Cryo-EM map 1 for the IgAseDS1\u2020:Fab\u2032DS1 recognition complex. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-58703. Deposited 4 August 2026."},{"key":"e_1_3_4_99_2","unstructured":"J. S. Ram\u00edrez-Larrota M. Gragera U. Eckhard F. X. Gomis-R\u00fcth Cryo-EM map 2 for the IgAseDS1\u2020:Fab\u2032DS1 recognition complex. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-58704. Deposited 4 August 2026."},{"key":"e_1_3_4_100_2","unstructured":"J. S. Ram\u00edrez-Larrota M. Gragera U. Eckhard F. X. Gomis-R\u00fcth Cryo-EM map 3 for the IgAseDS1\u2020:Fab\u2032DS1 precatalytic complex. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-58705. Deposited 4 August 2026."},{"key":"e_1_3_4_101_2","unstructured":"J. S. Ram\u00edrez-Larrota M. Gragera U. Eckhard F. X. Gomis-R\u00fcth Cryo-EM map 3 for the IgAseDS1\u2020:Fab\u2032DS1 recognition complex. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-58714. Deposited 4 August 2026."},{"key":"e_1_3_4_102_2","doi-asserted-by":"crossref","unstructured":"J. S. Ram\u00edrez-Larrota U. Eckhard F. X. Gomis-Ruth Diffraction data for the crystal structure of the Human IgA2 Fab fragment. European Synchrotron Radiation Facility. https:\/\/doi.esrf.fr\/10.15151\/ESRF-DC-2497672782. Deposited 2 September 2026.","DOI":"10.2210\/pdb31vy\/pdb"},{"key":"e_1_3_4_103_2","unstructured":"J. S. Ram\u00edrez-Larrota G. Effantin U. Eckhard F. X. Gomis-Ruth Cryo-EM raw data for the IgAse\u2013IgA2 Fab\u2032 complex. European Synchrotron Radiation Facility. https:\/\/doi.org\/10.15151\/ESRF-DC-2498320275. Deposited 2 September 2026."},{"key":"e_1_3_4_104_2","unstructured":"U. Eckhard G. Arasa M. L\u00f3pez-Mart\u00edn AlphaFold3 decoys molecular dynamics simulation trajectoriesand topology files along with the custom scripts for data analysis. Zenodo. https:\/\/doi.org\/10.5281\/zenodo.22232524. Deposited 1 September 2026."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2626241123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:39:44Z","timestamp":1792172384000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2626241123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,16]]},"references-count":104,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2026,10,20]]}},"alternative-id":["10.1073\/pnas.2626241123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2626241123","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,16]]},"assertion":[{"value":"2026-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2626241123"}}