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We demonstrate that dense polymer brushes reduce nonspecific protein adsorption in single-protein assays. By contrast, all CNC surfaces form dynamic coronas upon exposure to serum proteins, while specific polymer coatings selectively enrich or suppress distinct protein populations. We further demonstrate that polymer-dependent immune cell interactions are substantially reduced following protein corona formation, although differences among polymer chemistries persist. Zwitterionic coatings broadly suppress immune cell interactions, whereas PEG-based coatings preferentially promote interactions with antigen-presenting cells. 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