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We now consider whether \u03b54 carriers have these regional brain abnormalities as relatively young adults. Apolipoprotein E genotypes were established in normal volunteers 20\u201339 years of age. Clinical ratings, neuropsychological tests, magnetic resonance imaging, and PET were performed in 12 \u03b54 heterozygotes, all with the \u03b53\/\u03b54 genotype, and 15 noncarriers of the \u03b54 allele, 12 of whom were individually matched for sex, age, and educational level. An automated algorithm was used to generate an aggregate surface-projection map that compared regional PET measurements in the two groups. The young adult \u03b54 carriers and noncarriers did not differ significantly in their sex, age, educational level, clinical ratings, or neuropsychological test scores. Like previously studied patients with probable AD and late-middle-aged \u03b54 carriers, the young \u03b54 carriers had abnormally low rates of glucose metabolism bilaterally in the posterior cingulate, parietal, temporal, and prefrontal cortex. Carriers of a common Alzheimer's susceptibility gene have functional brain abnormalities in young adulthood, several decades before the possible onset of dementia.<\/jats:p>","DOI":"10.1073\/pnas.2635903100","type":"journal-article","created":{"date-parts":[[2004,1,6]],"date-time":"2004-01-06T13:12:57Z","timestamp":1073394777000},"page":"284-289","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":830,"title":["Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia"],"prefix":"10.1073","volume":"101","author":[{"given":"Eric M.","family":"Reiman","sequence":"first","affiliation":[{"name":"Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006; Departments of Psychiatry and Radiology, University of Arizona, Tucson, AZ 85724; Departments of Mathematics and Psychology, Arizona State University, Tempe, AZ 85287; Departments of Neurology and Psychology, Mayo Clinic, Scottsdale, AZ 85259; Department of Medicine (Neurology), Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC 27710; Department of Neuroscience, Mayo..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Chen","sequence":"additional","affiliation":[{"name":"Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006; Departments of Psychiatry and Radiology, University of Arizona, Tucson, AZ 85724; Departments of Mathematics and Psychology, Arizona State University, Tempe, AZ 85287; Departments of Neurology and Psychology, Mayo Clinic, Scottsdale, AZ 85259; Department of Medicine (Neurology), Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC 27710; Department of Neuroscience, Mayo..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene E.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006; Departments of Psychiatry and Radiology, University of Arizona, Tucson, AZ 85724; Departments of Mathematics and Psychology, Arizona State University, Tempe, AZ 85287; Departments of Neurology and Psychology, Mayo Clinic, Scottsdale, AZ 85259; Department of Medicine (Neurology), Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC 27710; Department of Neuroscience, Mayo..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Caselli","sequence":"additional","affiliation":[{"name":"Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006; Departments of Psychiatry and Radiology, University of Arizona, Tucson, AZ 85724; Departments of Mathematics and Psychology, Arizona State University, Tempe, AZ 85287; Departments of Neurology and Psychology, Mayo Clinic, Scottsdale, AZ 85259; Department of Medicine (Neurology), Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC 27710; Department of Neuroscience, Mayo..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bandy","sequence":"additional","affiliation":[{"name":"Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006; Departments of Psychiatry and Radiology, University of Arizona, Tucson, AZ 85724; Departments of Mathematics and Psychology, Arizona State University, Tempe, AZ 85287; Departments of Neurology and Psychology, Mayo Clinic, Scottsdale, AZ 85259; Department of Medicine (Neurology), Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC 27710; Department of Neuroscience, Mayo..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Osborne","sequence":"additional","affiliation":[{"name":"Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006; Departments of Psychiatry and Radiology, University of Arizona, Tucson, AZ 85724; Departments of Mathematics and Psychology, Arizona State University, Tempe, AZ 85287; Departments of Neurology and Psychology, Mayo Clinic, Scottsdale, AZ 85259; Department of Medicine (Neurology), Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC 27710; Department of Neuroscience, Mayo..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006; Departments of Psychiatry and Radiology, University of Arizona, Tucson, AZ 85724; Departments of Mathematics and Psychology, Arizona State University, Tempe, AZ 85287; Departments of Neurology and Psychology, Mayo Clinic, Scottsdale, AZ 85259; Department of Medicine (Neurology), Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC 27710; Department of Neuroscience, Mayo..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hardy","sequence":"additional","affiliation":[{"name":"Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006; 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