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A number of cervical cancer cell lines express the MIS type II receptor, and MIS inhibits the growth of both human papilloma virus-transformed and non-human papilloma virus-transformed cervical cell lines, with a more dramatic effect seen in the latter. As in the ovarian cancer cell line OVCAR8, suppression of growth of the C33A cervical cancer cell line by MIS is associated with induction of the p16 tumor suppressor protein. However, in contrast to OVCAR8 cells, induction of p130 and p107 appears to play an important role in the inhibition of growth of C33A cells by MIS. Finally, normal cervical tissue expresses the MIS type II receptor\n                    <jats:italic>in vivo<\/jats:italic>\n                    , supporting the idea that MIS could be a targeted therapy for cervical cancer.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2636900100","type":"journal-article","created":{"date-parts":[[2003,12,23]],"date-time":"2003-12-23T12:58:11Z","timestamp":1072184291000},"page":"15601-15606","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":71,"title":["Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107"],"prefix":"10.1073","volume":"100","author":[{"given":"Thanh U.","family":"Barbie","sequence":"first","affiliation":[{"name":"Pediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114; and Cancer Center, Massachusetts General Hospital, Charlestown, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Barbie","sequence":"additional","affiliation":[{"name":"Pediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114; and Cancer Center, Massachusetts General Hospital, Charlestown, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"MacLaughlin","sequence":"additional","affiliation":[{"name":"Pediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114; and Cancer Center, Massachusetts General Hospital, Charlestown, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamala","family":"Maheswaran","sequence":"additional","affiliation":[{"name":"Pediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114; and Cancer Center, Massachusetts General Hospital, Charlestown, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia K.","family":"Donahoe","sequence":"additional","affiliation":[{"name":"Pediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114; and Cancer Center, Massachusetts General Hospital, Charlestown, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2003,12,11]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.472712"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-54-5-1051"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198110000-00010"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(84)90066-0"},{"key":"e_1_3_2_5_2","first-page":"3488","volume":"5","year":"1999","unstructured":"Masiakos, P. 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