{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:19:36Z","timestamp":1791220776486,"version":"4.1.0"},"reference-count":28,"publisher":"National Academy of Sciences","issue":"26","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2003,12,23]]},"abstract":"<jats:p>\n                    Depletion of selected regulatory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell subsets induces the spontaneous onset of various immune or autoimmune disorders. It is not clear, however, whether a given subset, notably CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD25\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cells, protects from a wide spectrum of immune disorders, or whether specialized subsets of regulatory T cells control each given disease or group of diseases. We report here, using diabetes prone nonobese diabetic (NOD) mice, that depending on the regulatory T cells that are depleted, i.e., CD25\n                    <jats:sup>+<\/jats:sup>\n                    , CD62L\n                    <jats:sup>+<\/jats:sup>\n                    , or CD45RB\n                    <jats:sup>low<\/jats:sup>\n                    , distinct immune diseases appear after transfer into NOD severe combined immunodeficiency (SCID) recipients. Thus, reconstitution of NOD SCID mice with CD25\n                    <jats:sup>-<\/jats:sup>\n                    T cells induces major gastritis and late-onset diabetes, but no or mild colitis. Reconstitution with CD62L\n                    <jats:sup>-<\/jats:sup>\n                    T cells induces fulminant diabetes with no colitis or gastritis. Reconstitution with CD45RB\n                    <jats:sup>high<\/jats:sup>\n                    T cells induces major colitis with wasting disease and no or very moderate gastritis and diabetes. Major differences among the three regulatory T cell subsets are also seen\n                    <jats:italic>in vitro<\/jats:italic>\n                    . The bulk of suppressor cells inhibiting the proliferation of CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD25\n                    <jats:sup>-<\/jats:sup>\n                    T cells in coculture is concentrated within the CD25\n                    <jats:sup>+<\/jats:sup>\n                    but not the CD62L\n                    <jats:sup>+<\/jats:sup>\n                    or CD45RB\n                    <jats:sup>low<\/jats:sup>\n                    T cell subsets. Similarly, cytokine production patterns are significantly different for each regulatory T cell subset. Collectively, these data point to the diversity and organ selectivity of regulatory T cells controlling distinct autoimmune diseases whatever the underlying mechanisms.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2636971100","type":"journal-article","created":{"date-parts":[[2003,12,23]],"date-time":"2003-12-23T12:58:11Z","timestamp":1072184291000},"page":"15806-15811","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":95,"title":["Diversity of regulatory CD4\n                    <sup>+T<\/sup>\n                    cells controlling distinct organ-specific autoimmune diseases"],"prefix":"10.1073","volume":"100","author":[{"given":"Marie-Alexandra","family":"Alyanakian","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U580, and Institut F\u00e9d\u00e9ratif Necker Enfants Malades, Facult\u00e9 Necker Enfants Malades, 161 Rue de S\u00e8vres, 75015 Paris, France; and Laboratoire d'Anatomopathologie, H\u00f4pital Georges Pompidou, 20 Rue Leblanc, 75015 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvaine","family":"You","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U580, and Institut F\u00e9d\u00e9ratif Necker Enfants Malades, Facult\u00e9 Necker Enfants Malades, 161 Rue de S\u00e8vres, 75015 Paris, France; and Laboratoire d'Anatomopathologie, H\u00f4pital Georges Pompidou, 20 Rue Leblanc, 75015 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Damotte","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U580, and Institut F\u00e9d\u00e9ratif Necker Enfants Malades, Facult\u00e9 Necker Enfants Malades, 161 Rue de S\u00e8vres, 75015 Paris, France; and Laboratoire d'Anatomopathologie, H\u00f4pital Georges Pompidou, 20 Rue Leblanc, 75015 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Gouarin","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U580, and Institut F\u00e9d\u00e9ratif Necker Enfants Malades, Facult\u00e9 Necker Enfants Malades, 161 Rue de S\u00e8vres, 75015 Paris, France; and Laboratoire d'Anatomopathologie, H\u00f4pital Georges Pompidou, 20 Rue Leblanc, 75015 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Esling","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U580, and Institut F\u00e9d\u00e9ratif Necker Enfants Malades, Facult\u00e9 Necker Enfants Malades, 161 Rue de S\u00e8vres, 75015 Paris, France; and Laboratoire d'Anatomopathologie, H\u00f4pital Georges Pompidou, 20 Rue Leblanc, 75015 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Garcia","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U580, and Institut F\u00e9d\u00e9ratif Necker Enfants Malades, Facult\u00e9 Necker Enfants Malades, 161 Rue de S\u00e8vres, 75015 Paris, France; and Laboratoire d'Anatomopathologie, H\u00f4pital Georges Pompidou, 20 Rue Leblanc, 75015 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Havouis","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U580, and Institut F\u00e9d\u00e9ratif Necker Enfants Malades, Facult\u00e9 Necker Enfants Malades, 161 Rue de S\u00e8vres, 75015 Paris, France; and Laboratoire d'Anatomopathologie, H\u00f4pital Georges Pompidou, 20 Rue Leblanc, 75015 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucienne","family":"Chatenoud","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U580, and Institut F\u00e9d\u00e9ratif Necker Enfants Malades, Facult\u00e9 Necker Enfants Malades, 161 Rue de S\u00e8vres, 75015 Paris, France; and Laboratoire d'Anatomopathologie, H\u00f4pital Georges Pompidou, 20 Rue Leblanc, 75015 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Bach","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U580, and Institut F\u00e9d\u00e9ratif Necker Enfants Malades, Facult\u00e9 Necker Enfants Malades, 161 Rue de S\u00e8vres, 75015 Paris, France; and Laboratoire d'Anatomopathologie, H\u00f4pital Georges Pompidou, 20 Rue Leblanc, 75015 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2003,12,12]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri821"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1026"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.2.387"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/5.11.1461"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.4049\/jimmunol.161.5.2620","volume":"161","year":"1998","unstructured":"Herbelin, A., Gombert, J. 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