{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:25:46Z","timestamp":1781101546327,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"3","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1969,3]]},"abstract":"<jats:p>Two male diploid fibroblast strains, each carrying deficiency mutations at different X-linked loci (glucose-6-phosphate dehydrogenase and hypoxanthine-guanine-phosphoribosyltransferase) have been successfully hybridized. The resulting mononucleated hybrid cells have been shown to synthesize both normal gene products, indicating that both X chromosomes are functionally active in the hybrid cells. We believe this is the first reported example of intergenic complementation in fused human diploid cells.<\/jats:p>","DOI":"10.1073\/pnas.62.3.793","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:11:59Z","timestamp":1149041519000},"page":"793-799","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":61,"title":["EVIDENCE FOR INTERGENIC COMPLEMENTATION IN HYBRID CELLS DERIVED FROM TWO HUMAN DIPLOID STRAINS EACH CARRYING AN X-LINKED MUTATION"],"prefix":"10.1073","volume":"62","author":[{"given":"Marcello","family":"Siniscalco","sequence":"first","affiliation":[{"name":"ALBERT EINSTEIN COLLEGE OF MEDICINE, NEW YORK CITY"},{"name":"WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, PHILADELPHIA"},{"name":"NATIONAL INSTITUTES OF HEALTH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold P.","family":"Klinger","sequence":"additional","affiliation":[{"name":"ALBERT EINSTEIN COLLEGE OF MEDICINE, NEW YORK CITY"},{"name":"WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, PHILADELPHIA"},{"name":"NATIONAL INSTITUTES OF HEALTH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Eagle","sequence":"additional","affiliation":[{"name":"ALBERT EINSTEIN COLLEGE OF MEDICINE, NEW YORK CITY"},{"name":"WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, PHILADELPHIA"},{"name":"NATIONAL INSTITUTES OF HEALTH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Koprowski","sequence":"additional","affiliation":[{"name":"ALBERT EINSTEIN COLLEGE OF MEDICINE, NEW YORK CITY"},{"name":"WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, PHILADELPHIA"},{"name":"NATIONAL INSTITUTES OF HEALTH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfred Y.","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"ALBERT EINSTEIN COLLEGE OF MEDICINE, NEW YORK CITY"},{"name":"WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, PHILADELPHIA"},{"name":"NATIONAL INSTITUTES OF HEALTH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Edwin","family":"Seegmiller","sequence":"additional","affiliation":[{"name":"ALBERT EINSTEIN COLLEGE OF MEDICINE, NEW YORK CITY"},{"name":"WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, PHILADELPHIA"},{"name":"NATIONAL INSTITUTES OF HEALTH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1969,3]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.62.3.793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T09:52:19Z","timestamp":1649843539000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.62.3.793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1969,3]]}},"alternative-id":["10.1073\/pnas.62.3.793"],"URL":"https:\/\/doi.org\/10.1073\/pnas.62.3.793","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,3]]},"assertion":[{"value":"1969-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}