{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:44:51Z","timestamp":1781109891900,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"2","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1970,2]]},"abstract":"<jats:p>\n                    Chlorpromazine (3 \u00d7 10\n                    <jats:sup>-4<\/jats:sup>\n                    <jats:italic>M<\/jats:italic>\n                    ) prevents the stimulation of adenyl cyclase activity in thyroid membranes produced by thyrotropin and prostaglandin, ACTH stimulation of adenyl cyclase in adrenal tissue, and glucagon- and epinephrine-stimulation of adenyl cyclase activity in liver. Baseline activity is unaffected. Parathyroid hormone stimulation of kidney preparations was not inhibited under these conditions. At chlorpromazine concentrations &gt;3 \u00d7 10\n                    <jats:sup>-4<\/jats:sup>\n                    <jats:italic>M<\/jats:italic>\n                    F\n                    <jats:sup>-<\/jats:sup>\n                    -stimulated cyclase activity of thyroid and adrenal tissue was increased. Other phenothiazines, trifluoperazine, and prochlorperazine, have similar effects on thyrotropin and F\n                    <jats:sup>-<\/jats:sup>\n                    -stimulated cyclase activity of thyroid. Na\n                    <jats:sup>+<\/jats:sup>\n                    - K\n                    <jats:sup>+<\/jats:sup>\n                    -dependent ATPase of thyroid is also inhibited by chlorpromazine. Since thymol causes a similar dissociation of hormone- and F\n                    <jats:sup>-<\/jats:sup>\n                    -stimulated adenyl cyclase, it is concluded that the surface properties of these agents best account for their effects on adenyl cyclase.\n                  <\/jats:p>","DOI":"10.1073\/pnas.65.2.454","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:18:21Z","timestamp":1149041901000},"page":"454-459","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":59,"title":["Inhibition of Hormone-Sensitive Adenyl Cyclase by Phenothiazines"],"prefix":"10.1073","volume":"65","author":[{"given":"J.","family":"Wolff","sequence":"first","affiliation":[{"name":"NATIONAL INSTITUTE OF ARTHRITIS AND METABOLIC DISEASES, NATIONAL INSTITUTES OF HEALTH, BETHESDA, MARYLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann B.","family":"Jones","sequence":"additional","affiliation":[{"name":"NATIONAL INSTITUTE OF ARTHRITIS AND METABOLIC DISEASES, NATIONAL INSTITUTES OF HEALTH, BETHESDA, MARYLAND"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1970,2]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.65.2.454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:39:32Z","timestamp":1649846372000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.65.2.454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1970,2]]}},"alternative-id":["10.1073\/pnas.65.2.454"],"URL":"https:\/\/doi.org\/10.1073\/pnas.65.2.454","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,2]]},"assertion":[{"value":"1970-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}