{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:21:01Z","timestamp":1781108461348,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"3","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1970,11]]},"abstract":"<jats:p>\n                    A neurophysiological study of a behavioral phenotype caused by a sex-linked single gene mutation has been performed with gynandromorphs, mosaic for the mutant gene,\n                    <jats:italic>Hyperkinetic<\/jats:italic>\n                    <jats:sup>\n                      1\n                      <jats:italic>P<\/jats:italic>\n                    <\/jats:sup>\n                    (\n                    <jats:italic>Hk<\/jats:italic>\n                    <jats:sup>\n                      1\n                      <jats:italic>P<\/jats:italic>\n                    <\/jats:sup>\n                    ), in\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    . The male tissue of this gynandromorph is hemizygous for\n                    <jats:italic>Hk<\/jats:italic>\n                    <jats:sup>\n                      1\n                      <jats:italic>P<\/jats:italic>\n                    <\/jats:sup>\n                    , while the female tissue is heterozygous. The characteristic neural activity caused by the\n                    <jats:italic>Hk<\/jats:italic>\n                    <jats:sup>\n                      1\n                      <jats:italic>P<\/jats:italic>\n                    <\/jats:sup>\n                    gene can be recorded only in the presumptive male region of the thoracic ganglion. Motor regions of one side were found to function independently of their counterparts in the opposite side of the thoracic ganglion and were unaffected by the genotype of other parts of the body. Thus, expression of the\n                    <jats:italic>Hk<\/jats:italic>\n                    <jats:sup>\n                      1\n                      <jats:italic>P<\/jats:italic>\n                    <\/jats:sup>\n                    gene is autonomous in the genetic sense, and each side of the ganglion is independent of the other side. Also, there is a high correlation between the external genotype and the genotype of underlying neural tissue of the thorax.\n                  <\/jats:p>","DOI":"10.1073\/pnas.67.3.1480","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:23:48Z","timestamp":1149042228000},"page":"1480-1487","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":32,"title":["Unilaterally Patterned Neural Activity of Gynandromorphs, Mosaic for a Neurological Mutant of\n                    <i>Drosophila Melanogaster<\/i>"],"prefix":"10.1073","volume":"67","author":[{"given":"Kazuo","family":"Ikeda","sequence":"first","affiliation":[{"name":"DIVISION OF NEUROSCIENCES, CITY OF HOPE MEDICAL CENTER, DUARTE, CALIFORNIA 91010"},{"name":"DIVISION OF BIOLOGY, CITY OF HOPE MEDICAL CENTER, DUARTE, CALIFORNIA 91010"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"DIVISION OF NEUROSCIENCES, CITY OF HOPE MEDICAL CENTER, DUARTE, CALIFORNIA 91010"},{"name":"DIVISION OF BIOLOGY, CITY OF HOPE MEDICAL CENTER, DUARTE, CALIFORNIA 91010"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1970,11]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.67.3.1480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:38:29Z","timestamp":1649846309000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.67.3.1480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,11]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1970,11]]}},"alternative-id":["10.1073\/pnas.67.3.1480"],"URL":"https:\/\/doi.org\/10.1073\/pnas.67.3.1480","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,11]]},"assertion":[{"value":"1970-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}