{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:59:21Z","timestamp":1781103561626,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"4","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1970,12]]},"abstract":"<jats:p>\n                    Colchicine and other microtubule-active agents have been found to block the release, stimulated by either thyroid-stimulating hormone or by dibutyryl cyclic adenosine 3\u2032:5\u2032-monophosphate, of\n                    <jats:sup>131<\/jats:sup>\n                    I from previously\n                    <jats:sup>131<\/jats:sup>\n                    I-labeled mouse thyroid glands\n                    <jats:italic>in vitro<\/jats:italic>\n                    . The time and concentration characteristics of these inhibitors are consistent with their actions on microtubules in other systems. [\n                    <jats:sup>3<\/jats:sup>\n                    H]colchicine was also shown to be bound to a soluble 6S protein of bovine thyroid slices similar to the protein identified in other systems as a microtubular subunit. The demonstrated inhibition of colloid droplet formation and absence of an effect on thyroidal adenyl cyclase or cyclic 3\u2032:5\u2032-phosphodiesterase suggests a colchicine-sensitive role for microtubules in colloid endocytosis in the thyroid gland.\n                  <\/jats:p>","DOI":"10.1073\/pnas.67.4.1901","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:21:49Z","timestamp":1149042109000},"page":"1901-1908","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":91,"title":["Possible Role of Microtubules in Thyroid Secretion"],"prefix":"10.1073","volume":"67","author":[{"given":"John A.","family":"Williams","sequence":"first","affiliation":[{"name":"NATIONAL INSTITUTE OF ARTHRITIS AND METABOLIC DISEASES, NATIONAL INSTITUTES OF HEALTH, BETHESDA, MARYLAND 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wolff","sequence":"additional","affiliation":[{"name":"NATIONAL INSTITUTE OF ARTHRITIS AND METABOLIC DISEASES, NATIONAL INSTITUTES OF HEALTH, BETHESDA, MARYLAND 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1970,12]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.67.4.1901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:19:31Z","timestamp":1649845171000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.67.4.1901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,12]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1970,12]]}},"alternative-id":["10.1073\/pnas.67.4.1901"],"URL":"https:\/\/doi.org\/10.1073\/pnas.67.4.1901","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,12]]},"assertion":[{"value":"1970-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}