{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:20:32Z","timestamp":1781104832110,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"1","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1971,1]]},"abstract":"<jats:p>\n                    A \u03b31 protein, designated CRA, found in heavy chain disease contains three inter-heavy disulfide bridges instead of the two normally found in \u03b31 immunoglobulin heavy chains. Almost the entire Fd fragment is missing. The NH\n                    <jats:sub>2<\/jats:sub>\n                    terminal region is heterogeneous and contains carbohydrate; after 11 residues that do not resemble any of the known heavy-chain variable-region subclasses, normal synthesis seems to be resumed at the same amino acid residue as in another heavy-chain disease protein (ZUC). This finding raises the possibility that glutamic acid at position 216 represents the beginning of the Fe region, synthesized under the direction of another gene.\n                  <\/jats:p>","DOI":"10.1073\/pnas.68.1.187","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:24:15Z","timestamp":1149042255000},"page":"187-191","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":38,"title":["The Molecular Defect in a Protein (CRA) Found in \u03b31 Heavy Chain Disease, and Its Genetic Implications"],"prefix":"10.1073","volume":"68","author":[{"given":"E. C.","family":"Franklin","sequence":"first","affiliation":[{"name":"Department of Medicine and Rheumatic Diseases Study Group, New York University School of Medicine, N.Y. 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Frangione","sequence":"additional","affiliation":[{"name":"Department of Medicine and Rheumatic Diseases Study Group, New York University School of Medicine, N.Y. 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1971,1]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.68.1.187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:40:20Z","timestamp":1649846420000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.68.1.187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1971,1]]}},"alternative-id":["10.1073\/pnas.68.1.187"],"URL":"https:\/\/doi.org\/10.1073\/pnas.68.1.187","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,1]]},"assertion":[{"value":"1971-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}