{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:06:18Z","timestamp":1785834378527,"version":"3.56.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"2","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1971,2]]},"abstract":"<jats:p>The effects of the administration of normal human plasma to patients affected by mucopolysaccharidoses I and II (Hurler's and Hunter's syndromes) have been evaluated. The infusion was followed by a decreased urinary excretion of relatively large molecular weight glycosaminoglycans and by an increased excretion of their products of degradation. Among the latter, products of the degradation of dermatan sulfate and heparan sulfate could be demonstrated.<\/jats:p>\n                  <jats:p>The results indicate that normal human plasma may contain those \u201cfactors\u201d that are involved in the normal degradation of dermatan sulfate and heparan sulfate, that are missing in the diseased states.<\/jats:p>","DOI":"10.1073\/pnas.68.2.303","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:27:20Z","timestamp":1149042440000},"page":"303-307","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":108,"title":["Induced Degradation of Glycosaminoglycans in Hurler's and Hunter's Syndromes by Plasma Infusion"],"prefix":"10.1073","volume":"68","author":[{"given":"Nicola Di","family":"Ferrante","sequence":"first","affiliation":[{"name":"Laboratories of Connective Tissue Research, Department of Biochemistry Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"},{"name":"Division of Orthopedic Surgery, Department of Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"},{"name":"Department of Pediatrics, Clinical Research Center, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buford L.","family":"Nichols","sequence":"additional","affiliation":[{"name":"Laboratories of Connective Tissue Research, Department of Biochemistry Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"},{"name":"Division of Orthopedic Surgery, Department of Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"},{"name":"Department of Pediatrics, Clinical Research Center, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia V.","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Laboratories of Connective Tissue Research, Department of Biochemistry Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"},{"name":"Division of Orthopedic Surgery, Department of Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"},{"name":"Department of Pediatrics, Clinical Research Center, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Neri","sequence":"additional","affiliation":[{"name":"Laboratories of Connective Tissue Research, Department of Biochemistry Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"},{"name":"Division of Orthopedic Surgery, Department of Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"},{"name":"Department of Pediatrics, Clinical Research Center, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruzica","family":"Hrgovcic","sequence":"additional","affiliation":[{"name":"Laboratories of Connective Tissue Research, Department of Biochemistry Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"},{"name":"Division of Orthopedic Surgery, Department of Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"},{"name":"Department of Pediatrics, Clinical Research Center, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Berglund","sequence":"additional","affiliation":[{"name":"Laboratories of Connective Tissue Research, Department of Biochemistry Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"},{"name":"Division of Orthopedic Surgery, Department of Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"},{"name":"Department of Pediatrics, Clinical Research Center, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77025"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1971,2]]},"container-title":["Proceedings of the National Academy of 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