{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:43:54Z","timestamp":1781109834184,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1972,10]]},"abstract":"<jats:p>\n                    The cytotoxic action of lymphocytes upon cells bearing alloantigens to which they are sensitized is inhibited by agents that elevate intracellular amounts of 3\u2032:5\u2032-cyclic AMP: prostaglandin E\n                    <jats:sub>1<\/jats:sub>\n                    , cholera toxin, and theophylline. Cholinergic agents, added in the range of 1 to 100 pM, enhance cytotoxicity, an effect that is blocked by atropine. Because cholinergic agents elevate cyclic GMP in other\n                    <jats:italic>in vitro<\/jats:italic>\n                    systems, these findings suggest that the cytotoxic process effected by sensitized lymphocytes is a secretory phenomenon modulated by cyclic AMP and cyclic GMP.\n                  <\/jats:p>","DOI":"10.1073\/pnas.69.10.2995","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:32:40Z","timestamp":1149042760000},"page":"2995-2999","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":91,"title":["Alteration of the Cytotoxic Action of Sensitized Lymphocytes by Cholinergic Agents and Activators of Adenylate Cyclase"],"prefix":"10.1073","volume":"69","author":[{"given":"Terry B.","family":"Strom","sequence":"first","affiliation":[{"name":"Department of Medicine, Peter Bent Brigham Hospital, and Beth Israel Hospital, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Deisseroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Morganroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Medicine, Peter Bent Brigham Hospital, and Beth Israel Hospital, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Merrill","sequence":"additional","affiliation":[{"name":"Department of Medicine, Peter Bent Brigham Hospital, and Beth Israel Hospital, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1972,10]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.69.10.2995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:43:11Z","timestamp":1649846591000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.69.10.2995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1972,10]]}},"alternative-id":["10.1073\/pnas.69.10.2995"],"URL":"https:\/\/doi.org\/10.1073\/pnas.69.10.2995","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,10]]},"assertion":[{"value":"1972-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}