{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:30:17Z","timestamp":1781105417785,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"3","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1972,3]]},"abstract":"<jats:p>A hydrogen-bonding interaction between phenobarbital or pentobarbital with phosphatidylcholine in chloroform is indicated by the effects of added phosphatidylcholine on the infrared and proton magnetic resonance spectra of these barbiturates. The nitrogenbound proton of the barbiturate and the orthophosphate moiety of the phosphatidylcholine molecule appear to be involved. The more pronounced effect with the two barbiturates occurs in the proton magnetic resonance spectra of phenobarbital with increased amounts of phosphatidylcholine. A plot of the chemical shift of phenobarbital N\u2014H against the concentration of phosphatidylcholine is linear and gives an extrapolated shift of 260 Hz (2.6 ppm) at 35\u00b0C for a phosphatidylcholine-phenobarbital ratio of unity, pure 1:1 complex. It is suggested that the general depressant nature of barbiturates may be accounted for by their association in a similar fashion with a number of other phosphate-containing molecules.<\/jats:p>","DOI":"10.1073\/pnas.69.3.640","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:33:44Z","timestamp":1149042824000},"page":"640-642","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":10,"title":["Barbiturate Interaction with Phosphatidylcholine"],"prefix":"10.1073","volume":"69","author":[{"given":"Raymond F.","family":"Novak","sequence":"first","affiliation":[{"name":"Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106"},{"name":"Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Swift","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106"},{"name":"Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1972,3]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.69.3.640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:36:46Z","timestamp":1649846206000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.69.3.640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1972,3]]}},"alternative-id":["10.1073\/pnas.69.3.640"],"URL":"https:\/\/doi.org\/10.1073\/pnas.69.3.640","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,3]]},"assertion":[{"value":"1972-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}