{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:50:32Z","timestamp":1790797832213,"version":"4.1.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"6","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1972,6]]},"abstract":"<jats:p>\n                    The group-specific protein reagent,\n                    <jats:italic>N<\/jats:italic>\n                    -ethylmaleimide, irreversibly blocks the electrical response of the olfactory receptor organ of the frog to odorous stimuli. If the odorous substance, ethyl\n                    <jats:italic>n<\/jats:italic>\n                    -butyrate, in concentrations high enough to saturate the receptor system, is present in the nasal cavity before and during a brief exposure to\n                    <jats:italic>N<\/jats:italic>\n                    -ethylmaleimide, the nose, after a wash and a recovery period, responds in nearly normal fashion to vapors of ethyl\n                    <jats:italic>n<\/jats:italic>\n                    -butyrate. Responses to other odorous substances, except those closely related to ethyl\n                    <jats:italic>n<\/jats:italic>\n                    -butyrate, are abolished. We propose that we can use this protection technique to identify the properties of the various receptor sites in the nose, and possibly to characterize the receptor substances.\n                  <\/jats:p>","DOI":"10.1073\/pnas.69.6.1494","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:36:33Z","timestamp":1149042993000},"page":"1494-1498","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["The Chemistry of Olfactory Reception: Stimulus-Specific Protection from Sulfhydryl Reagent Inhibition"],"prefix":"10.1073","volume":"69","author":[{"given":"Marilyn Levisohn","family":"Getchell","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Northwestern University, Evanston, Illinois 60201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Gesteland","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Northwestern University, Evanston, Illinois 60201"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1972,6]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.69.6.1494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:46:21Z","timestamp":1649846781000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.69.6.1494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1972,6]]}},"alternative-id":["10.1073\/pnas.69.6.1494"],"URL":"https:\/\/doi.org\/10.1073\/pnas.69.6.1494","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,6]]},"assertion":[{"value":"1972-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}