{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:38:10Z","timestamp":1781105890623,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"6","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1972,6]]},"abstract":"<jats:p>\n                    The nuclear synthesis of adenovirus-specific RNA late in the infectious cycle in the presence of toyocamycin (an adenosine analogue) has been investigated. There is reduced synthesis of viral RNA with an accumulation of virus-specific RNA in the molecular weight range of at least 4 to 8 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    . No new viral RNA associates with cytoplasmic polyribosomes. In addition, hybridization competition experiments indicate a 70% competition between these large nuclear transcripts and polyribosome-associated viral RNA that was synthesized in the absence of inhibitor. These data are consistent with the following interpretations: complete nuclear processing of viral RNA is necessary for polyribosome association, and precursor viral message(s) contain sequences that are lost normally during post-transcriptional processing.\n                  <\/jats:p>","DOI":"10.1073\/pnas.69.6.1578","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:36:33Z","timestamp":1149042993000},"page":"1578-1582","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":26,"title":["Adenovirus Messenger RNA in Mammalian Cells: Failure of Polyribosome Association in the Absence of Nuclear Cleavage"],"prefix":"10.1073","volume":"69","author":[{"given":"P. M.","family":"McGuire","sequence":"first","affiliation":[{"name":"Department of Microbiology, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Swart","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. D.","family":"Hodge","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1972,6]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.69.6.1578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:45:59Z","timestamp":1649846759000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.69.6.1578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1972,6]]}},"alternative-id":["10.1073\/pnas.69.6.1578"],"URL":"https:\/\/doi.org\/10.1073\/pnas.69.6.1578","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,6]]},"assertion":[{"value":"1972-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}