{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:15:19Z","timestamp":1781104519943,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1972,9]]},"abstract":"<jats:p>Reaction of antibody to surface Histocompatibility-2 antigens of cultured mouse fibroblasts causes aggregation of the cellular antigens into caps; these appear as areas of high antigen concentration localized away from the cell processes. Cap formation is inhibited when ATP generation by cells is interrupted, when the temperature is lowered, by addition of cycloheximide\u2014especially over long time periods\u2014and by colcemid. The observations are consistent with a role of the locomotor system of cells in the collection of small antigen-antibody aggregates into a large localized cap. Together with observations on the absence of caps in epithelial cells, these findings suggest that only cells, such as fibroblasts and lymphocytes, that bear leading ruffled membranes are capable of driving antigenantibody aggregates to form caps.<\/jats:p>","DOI":"10.1073\/pnas.69.9.2456","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:38:45Z","timestamp":1149043125000},"page":"2456-2459","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":105,"title":["Antigen Cap Formation in Cultured Fibroblasts: A Reflection of Membrane Fluidity and of Cell Motility"],"prefix":"10.1073","volume":"69","author":[{"given":"Michael","family":"Edidin","sequence":"first","affiliation":[{"name":"Biology Department, The Johns Hopkins University, Baltimore, Maryland 21218"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Weiss","sequence":"additional","affiliation":[{"name":"Biology Department, The Johns Hopkins University, Baltimore, Maryland 21218"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1972,9]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.69.9.2456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:48:53Z","timestamp":1649846933000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.69.9.2456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1972,9]]}},"alternative-id":["10.1073\/pnas.69.9.2456"],"URL":"https:\/\/doi.org\/10.1073\/pnas.69.9.2456","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,9]]},"assertion":[{"value":"1972-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}