{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:05:04Z","timestamp":1781107504940,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1973,9]]},"abstract":"<jats:p>\n                    A new system of lymphocyte alloantigens in mice is described. This\n                    <jats:italic>Lna<\/jats:italic>\n                    (lymph-node antigen) system is associated with the\n                    <jats:italic>Ir<\/jats:italic>\n                    region of the\n                    <jats:italic>H-2<\/jats:italic>\n                    (histocompatibility-2) gene complex. It has the following distinctive characteristics: (\n                    <jats:italic>1<\/jats:italic>\n                    ) The gene or genes controlling these antigens has been mapped in the\n                    <jats:italic>Ir<\/jats:italic>\n                    (immune response) region between\n                    <jats:italic>H-2K<\/jats:italic>\n                    and\n                    <jats:italic>Ss-Slp<\/jats:italic>\n                    . (\n                    <jats:italic>2<\/jats:italic>\n                    ) The antigens are most readily detectable on lymph-node cells, although they are also expressed on peripheral blood lymphocytes, splenic lymphocytes, and thymocytes. (\n                    <jats:italic>3<\/jats:italic>\n                    ) Cytotoxicity against only about half of lymph-node cells is consistently observed. (\n                    <jats:italic>4<\/jats:italic>\n                    ) Cytotoxic antibody titers against these antigens are strikingly high\u2014more than 2000 by\n                    <jats:sup>51<\/jats:sup>\n                    Cr-release and up to 100,000 in the microcytotoxic test. (\n                    <jats:italic>5<\/jats:italic>\n                    ) At least two, probably allelic, forms of the antigen(s) have been defined, one associated with the\n                    <jats:italic>H-2<\/jats:italic>\n                    <jats:sup>k<\/jats:sup>\n                    haplotype and one with the\n                    <jats:italic>H-2<\/jats:italic>\n                    <jats:sup>a<\/jats:sup>\n                    haplotype. (\n                    <jats:italic>6<\/jats:italic>\n                    ) Antisera against\n                    <jats:italic>Lna<\/jats:italic>\n                    contain multiple antibody specificities that can be fractionated by absorption either with certain recombinants or with other\n                    <jats:italic>H-2<\/jats:italic>\n                    halotypes that have crossreactive antigens. The antisera against\n                    <jats:italic>Lna<\/jats:italic>\n                    may be of value for definition and characterization of the products of the\n                    <jats:italic>Ir<\/jats:italic>\n                    and\n                    <jats:italic>MLR<\/jats:italic>\n                    (mixed lymphocyte reaction stimulatory) genes associated with the\n                    <jats:italic>H-2<\/jats:italic>\n                    complex.\n                  <\/jats:p>","DOI":"10.1073\/pnas.70.9.2509","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:45:25Z","timestamp":1149043525000},"page":"2509-2514","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":202,"title":["New Lymphocyte Antigen System (\n                    <i>Lna<\/i>\n                    ) Controlled by the\n                    <i>Ir<\/i>\n                    Region of the Mouse\n                    <i>H-2<\/i>\n                    Complex"],"prefix":"10.1073","volume":"70","author":[{"given":"C. S.","family":"David","sequence":"first","affiliation":[{"name":"Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Mich. 48104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"Shreffler","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Mich. 48104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Frelinger","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Mich. 48104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1973,9]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.70.9.2509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:45:12Z","timestamp":1649846712000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.70.9.2509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1973,9]]}},"alternative-id":["10.1073\/pnas.70.9.2509"],"URL":"https:\/\/doi.org\/10.1073\/pnas.70.9.2509","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,9]]},"assertion":[{"value":"1973-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}