{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:44:57Z","timestamp":1781109897674,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"1","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1974,1]]},"abstract":"<jats:p>\n                    Hybrids between different human cells (which synthesize cholesterol) and mouse cells (whose end-product of sterol synthesis is desmosterol) were analyzed for the ability to convert desmosterol to cholesterol. Conversion of [\n                    <jats:sup>14<\/jats:sup>\n                    C]desmosterol to cholesterol and incorporation of [\n                    <jats:sup>14<\/jats:sup>\n                    C]acetate into the end-product sterol were studied in the parental and hybrid cells. Concordant segregation of the conversion of desmosterol to cholesterol and the human chromosome F-20 was observed.\n                  <\/jats:p>","DOI":"10.1073\/pnas.71.1.110","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:46:14Z","timestamp":1149043574000},"page":"110-113","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":7,"title":["Restoration of the Conversion of Desmosterol to Cholesterol in L-Cells after Hybridization with Human Fibroblasts"],"prefix":"10.1073","volume":"71","author":[{"given":"C. M.","family":"Croce","sequence":"first","affiliation":[{"name":"The Wistar Institute, 36th Street at Spruce, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kieba","sequence":"additional","affiliation":[{"name":"The Wistar Institute, 36th Street at Spruce, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Koprowski","sequence":"additional","affiliation":[{"name":"The Wistar Institute, 36th Street at Spruce, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Molino","sequence":"additional","affiliation":[{"name":"The Wistar Institute, 36th Street at Spruce, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. H.","family":"Rothblat","sequence":"additional","affiliation":[{"name":"The Wistar Institute, 36th Street at Spruce, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1974,1]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.71.1.110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:22:44Z","timestamp":1649845364000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.71.1.110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1974,1]]}},"alternative-id":["10.1073\/pnas.71.1.110"],"URL":"https:\/\/doi.org\/10.1073\/pnas.71.1.110","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,1]]},"assertion":[{"value":"1974-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}