{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:41:08Z","timestamp":1781109668431,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"1","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1974,1]]},"abstract":"<jats:p>\n                    Calcium acting through the ionophore A-23187 caused massive K\n                    <jats:sup>+<\/jats:sup>\n                    release from rat parotid slices. The ionophore thus simulates the action of epinephrine on the \u03b1-adrenergic receptor in this system. The \u03b1-adrenergic and cholinergic receptors are, however, not involved in the action of the ionophore since phetolamine and atropine had no effect on the ionophore-induced K\n                    <jats:sup>+<\/jats:sup>\n                    release. Amylase secretion, which is induced by epinephrine through the \u03b2-adrenergic receptor but does not require Ca\n                    <jats:sup>++<\/jats:sup>\n                    in the medium, was only slightly increased by the ionophore in the presence of Ca\n                    <jats:sup>++<\/jats:sup>\n                    . The K\n                    <jats:sup>+<\/jats:sup>\n                    released by Ca\n                    <jats:sup>++<\/jats:sup>\n                    through the ionophore was regained by the cells upon chelation of Ca\n                    <jats:sup>++<\/jats:sup>\n                    with ethylene glycol bis(\u03b2-aminoethyl ether)-\n                    <jats:italic>N,N<\/jats:italic>\n                    \u2032-tetraacetic acid. Similar to the action of epinephrine on the \u03b1-adrenergic receptor, the K\n                    <jats:sup>+<\/jats:sup>\n                    release induced by the ionophore is specific for Ca\n                    <jats:sup>++<\/jats:sup>\n                    , which cannot be substituted by 2.5 mM Sr\n                    <jats:sup>++<\/jats:sup>\n                    , Mg\n                    <jats:sup>++<\/jats:sup>\n                    , or Ba\n                    <jats:sup>++<\/jats:sup>\n                    . The results suggest that epinephrine, like the ionophore, introduces Ca\n                    <jats:sup>++<\/jats:sup>\n                    into the cell to mediate K\n                    <jats:sup>+<\/jats:sup>\n                    release. It is proposed that the ionophore A-23187 may be an effective probe to test whether other Ca\n                    <jats:sup>++<\/jats:sup>\n                    -requiring hormones and neurotransmitters act in a similar fashion to produce their diverse physiological responses.\n                  <\/jats:p>","DOI":"10.1073\/pnas.71.1.128","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:46:14Z","timestamp":1149043574000},"page":"128-131","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":87,"title":["A Calcium Ionophore Simulating the Action of Epinephrine on the \u03b1-Adrenergic Receptor"],"prefix":"10.1073","volume":"71","author":[{"given":"Zvi","family":"Selinger","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry, The Hebrew University of Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Eimerl","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, The Hebrew University of Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schramm","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, The Hebrew University of Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1974,1]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.71.1.128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:22:17Z","timestamp":1649845337000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.71.1.128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1974,1]]}},"alternative-id":["10.1073\/pnas.71.1.128"],"URL":"https:\/\/doi.org\/10.1073\/pnas.71.1.128","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,1]]},"assertion":[{"value":"1974-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}