{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:17:59Z","timestamp":1781108279516,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1974,10]]},"abstract":"<jats:p>\n                    Neuronal microtubules in a variety of nerve cell types are unaffected by high hydrostatic pressures over a range of 1400-10,000 pounds\/inch\n                    <jats:sup>2<\/jats:sup>\n                    and periods of 10-45 min. Similarly, purified tubulin polymerized to form microtubules\n                    <jats:italic>in vitro<\/jats:italic>\n                    were not depolymerized by the same range of pressures. The depolymerization of microtubules in several types of non-neuronal cells, which has been reported, may have been over-generalized with regard to the direct action of pressure on microtubule stability.\n                  <\/jats:p>","DOI":"10.1073\/pnas.71.10.4198","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:48:12Z","timestamp":1149043692000},"page":"4198-4202","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":20,"title":["Stability of Neuronal Microtubules to High Pressure\n                    <i>In Vivo<\/i>\n                    and\n                    <i>In Vitro<\/i>"],"prefix":"10.1073","volume":"71","author":[{"given":"Thomas M.","family":"O'Connor","sequence":"first","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Kansas, Lawrence, Kans. 66045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. L.","family":"Houston","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Kansas, Lawrence, Kans. 66045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Samson","sequence":"additional","affiliation":[{"name":"Ralph Smith Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, Kans. 66103"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1974,10]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.71.10.4198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:39:32Z","timestamp":1649846372000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.71.10.4198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1974,10]]}},"alternative-id":["10.1073\/pnas.71.10.4198"],"URL":"https:\/\/doi.org\/10.1073\/pnas.71.10.4198","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,10]]},"assertion":[{"value":"1974-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}