{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:37:04Z","timestamp":1781105824256,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"5","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1974,5]]},"abstract":"<jats:p>The vast majority of human lymphoid neoplasms examined to date have been associated with a proliferation of bone marrow-dependent (B) lymphocytes. In an effort to delineate human tumors of T-cell (thymusdependent) lineage, use was made of the peripheral blood leukocytes of sixteen subjects with various forms of mycosis fungoides. The abnormal cells in the circulation of these patients are morphologically identical to those that infiltrate their nodes and skin. On electron microscopy, such neoplastic lymphocytes (S\u00e9zary cells) had \u201ccerebriform\u201d nuclei and an abundance of cytoplasmic fibrils not described heretofore. S\u00e9zary cells were nonadherent and nonphagocytic and usually responded to stimulation with phytohemagglutinin, refuting earlier suggestions that the cells represent monocytes or histiocytes. In contrast to chronic lymphocytic leukemia lymphocytes, the S\u00e9zary cells lacked surface immunoglobulin and receptors for complement. Ultrastructural analysis identified S\u00e9zary cells in the center of directly formed rosettes (E-rosettes) characterizing the behavior of T lymphocytes in this test. Though some S\u00e9zary cells lacked both T and B cell-surface properties, in general, these observations support the view that the S\u00e9zary cell is a neoplastic variant of a thymusderived lymphocyte.<\/jats:p>","DOI":"10.1073\/pnas.71.5.1877","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:55:31Z","timestamp":1149044131000},"page":"1877-1881","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":88,"title":["Ultrastructural, Immunologic, and Functional Studies on S\u00e9zary Cells: A Neoplastic Variant of Thymus-Derived (T) Lymphocytes"],"prefix":"10.1073","volume":"71","author":[{"given":"Dorothea","family":"Zucker-Franklin","sequence":"first","affiliation":[{"name":"Department of Medicine, Rheumatic Diseases Study Group, New York University Medical Center, New York, N.Y. 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"John W.","family":"Melton","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rheumatic Diseases Study Group, New York University Medical Center, New York, N.Y. 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Quagliata","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rheumatic Diseases Study Group, New York University Medical Center, New York, N.Y. 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1974,5]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.71.5.1877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:25:31Z","timestamp":1649845531000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.71.5.1877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1974,5]]}},"alternative-id":["10.1073\/pnas.71.5.1877"],"URL":"https:\/\/doi.org\/10.1073\/pnas.71.5.1877","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,5]]},"assertion":[{"value":"1974-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}