{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:35:44Z","timestamp":1781109344239,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"6","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1974,6]]},"abstract":"<jats:p>\n                    Rifazone-8\n                    <jats:sub>2<\/jats:sub>\n                    , a new rifamycin derivative, is shown to preferentially inhibit the growth of virus-transformed chick cells in culture. Macromolecular synthesis and glucose uptake of transformed cells are also appreciably decreased in the presence of low concentrations of rifazone-8\n                    <jats:sub>2<\/jats:sub>\n                    where the normal cells appear unaffected. While rifazone-8\n                    <jats:sub>2<\/jats:sub>\n                    is shown to be a selective inhibitor of RNA-directed DNA polymerase\n                    <jats:italic>in vitro<\/jats:italic>\n                    , its action on the growth of transformed cells may involve some other mechanism.\n                  <\/jats:p>","DOI":"10.1073\/pnas.71.6.2520","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:56:34Z","timestamp":1149044194000},"page":"2520-2524","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":12,"title":["Preferential Inhibition of the Growth of Virus-Transformed Cells in Culture by Rifazone-8\n                    <sub>2<\/sub>\n                    , a New Rifamycin Derivative"],"prefix":"10.1073","volume":"71","author":[{"given":"Mina J.","family":"Bissell","sequence":"first","affiliation":[{"name":"Laboratory of Chemical Biodynamics, Lawrence Berkeley Laboratory, University of California, Berkeley, Calif. 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carroll","family":"Hatie","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biodynamics, Lawrence Berkeley Laboratory, University of California, Berkeley, Calif. 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan N.","family":"Tischler","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biodynamics, Lawrence Berkeley Laboratory, University of California, Berkeley, Calif. 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin","family":"Calvin","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biodynamics, Lawrence Berkeley Laboratory, University of California, Berkeley, Calif. 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1974,6]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.71.6.2520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:27:08Z","timestamp":1649845628000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.71.6.2520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1974,6]]}},"alternative-id":["10.1073\/pnas.71.6.2520"],"URL":"https:\/\/doi.org\/10.1073\/pnas.71.6.2520","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,6]]},"assertion":[{"value":"1974-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}