{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:14:33Z","timestamp":1789629273963,"version":"build-2803163510"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"1","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:p>\n                    Several immunologic features were analyzed in mice on a zinc-deficient diet [Zn(-)], in mice pair-fed a diet containing zinc [Zn(+)], in mice fed a Zn(+) diet ad lib, and in mice fed laboratory chow ad lib. When placed on a Zn(-) diet, 6- to 8-week-old A\/Jax, C57BL\/Ks, and CBA\/H mice showed loss of body weight, low lymphoid tissue weight, and profound involution of the thymus within 4-8 weeks after initiation of the regimen. Approximately 50% of the mice on the Zn(-) diet developed severe acrodermatitis enteropathica (lesions on tail and paws) and diarrhea. Pair-fed mice on the Zn(+) diet did not show any of these symptoms. Mice on the Zn(-) diet showed the following immune deficiencies: (\n                    <jats:italic>i<\/jats:italic>\n                    ) depressed plaque-forming cells against sheep erythrocytes after\n                    <jats:italic>in vivo<\/jats:italic>\n                    immunization; (\n                    <jats:italic>ii<\/jats:italic>\n                    ) depressed T killer cell activity against EL-4 tumor cells after\n                    <jats:italic>in vivo<\/jats:italic>\n                    immunization; and (\n                    <jats:italic>iii<\/jats:italic>\n                    ) low natural killer cell activity. However, antibody-dependent cell-mediated cytotoxicity against chicken erythrocytes was normal in the mice on the Zn(-) diet. Deficiency of T killer cell activity was not observed when immunization with EL-4 allogeneic lymphoma cells was carried out\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Progressive loss of relative and absolute number of Thy 1.2+ cells and a proportionate relative increase in cells bearing Fc receptors was seen in spleen and lymph nodes of Zn(-) animals. It appears that zinc is an essential element for maintenance of normal T cell and other immune functions\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1073\/pnas.76.1.457","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T03:47:56Z","timestamp":1149047276000},"page":"457-461","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":239,"title":["Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice"],"prefix":"10.1073","volume":"76","author":[{"given":"Gabriel","family":"Fernandes","sequence":"first","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavan","family":"Nair","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Onoe","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Floyd","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Good","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York, New York 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1979,1]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.76.1.457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T10:51:15Z","timestamp":1649847075000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.76.1.457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1073\/pnas.76.1.457"],"URL":"https:\/\/doi.org\/10.1073\/pnas.76.1.457","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]},"assertion":[{"value":"1979-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}