{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:23:26Z","timestamp":1781105006527,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1982,5]]},"abstract":"<jats:p>We evaluated the effects of therapy with a small dose (0.5 microgram\/day) of 1,25-dihydroxyvitamin D3 in 12 previously untreated patients with postmenopausal osteoporosis. Combined radiocalcium kinetic and balance studies showed that at base line, net calcium absorption (mean +\/- SEM) was low (7 +\/- 3%), calcium balance was negative (-59 +\/- 22 mg\/day), and bone resorption rate (297 +\/- 40 mg\/day) exceeded bone formation rate (239 +\/- 36 mg\/day). After short-term therapy (6-8 months), calcium absorption was normal (27 +\/- 3%, P less than 0.001 for difference from base line), calcium balance had improved (+2 +\/- 26 mg\/day, P less than 0.05), and bone resorption rate (195 +\/- 35 mg\/day, P less than 0.01) had decreased more than bone formation rate (197 +\/- 26 mg\/day, NS). Compared with base-line values, after long-term therapy (2 years) the increased level of calcium absorption was maintained (27 +\/- 3%, P less than 0.001), but calcium retention declined to a level intermediate (-27 +\/- 24 mg\/day, NS) between base-line and short-term treatment values, and both bone resorption rate (294 +\/- 33 mg\/day, NS) and bone formation rate (267 +\/- 34 mg\/day, NS) increased. Urinary hydroxyproline excretion was lower than before treatment (26.3 +\/-2.0 mg\/day) after both short-term (21.1 +\/- 1.6 mg\/day, P less than 0.001) and long-term (22.0 +\/- 1.8 mg\/day, P less than 0.01) treatments. Trabecular bone volume was 11.3 +\/- 1.0% at base line and increased to 16.0 +\/- 1.2% (P less than 0.01) after long-term treatment. By contrast, the eight patients studied before and after 6-8 months of placebo treatment had no significant change in any variable.<\/jats:p>","DOI":"10.1073\/pnas.79.10.3325","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T04:49:50Z","timestamp":1149050990000},"page":"3325-3329","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":128,"title":["1,25-Dihydroxyvitamin D3: short- and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis."],"prefix":"10.1073","volume":"79","author":[{"given":"J C","family":"Gallagher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Jerpbak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W S","family":"Jee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K A","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H F","family":"DeLuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B L","family":"Riggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1982,5]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.79.10.3325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T11:37:33Z","timestamp":1649849853000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.79.10.3325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,5]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1982,5]]}},"alternative-id":["10.1073\/pnas.79.10.3325"],"URL":"https:\/\/doi.org\/10.1073\/pnas.79.10.3325","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,5]]},"assertion":[{"value":"1982-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}