{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:09:54Z","timestamp":1781107794561,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1982,5]]},"abstract":"<jats:p>Horizontal cells of the carp retina possess dopamine receptors linked to adenylate cyclase. Isolated, intact horizontal cells respond to micromolar concentrations of dopamine, whereas nanomolar concentrations of haloperidol, (+)-butaclamol, and flupenthixol block the dopamine response. Preincubation in Ringer's solution containing increased levels of Ca2+ (5-110 mM) decreases the sensitivity of the cells to these antagonists by 1,000-10,000 times. Dopamine sensitivity of the cells is not affected by Ca2+ levels in the preincubation medium. Preincubation of the cells in Ringer's solution containing 500 microM L-glutamate, an agent that increases intracellular Ca2+ levels in intact horizontal cells, also decreases the sensitivity of the cells to haloperidol. These data suggest that antagonist sensitivity of intact horizontal cells may be regulated by intracellular Ca2+.<\/jats:p>","DOI":"10.1073\/pnas.79.10.3350","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T04:49:50Z","timestamp":1149050990000},"page":"3350-3354","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":3,"title":["Calcium alters the sensitivity of intact horizontal cells to dopamine antagonists."],"prefix":"10.1073","volume":"79","author":[{"given":"R","family":"Van Buskirk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Dowling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1982,5]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.79.10.3350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T11:37:22Z","timestamp":1649849842000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.79.10.3350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,5]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1982,5]]}},"alternative-id":["10.1073\/pnas.79.10.3350"],"URL":"https:\/\/doi.org\/10.1073\/pnas.79.10.3350","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,5]]},"assertion":[{"value":"1982-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}