{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:37:22Z","timestamp":1781105842828,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"7","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1983,4]]},"abstract":"<jats:p>Burkitt lymphomas contain reciprocal translocations between chromosome 8 and one of the chromosomes containing the immunoglobulin gene loci, prompting speculation that consequent activation of a crucial gene(s) on chromosome 8 might be involved in the generation of these tumors. Recently the human counterparts of the retroviral oncogenes v-myc and v-mos have been mapped to chromosome 8. We have, therefore, analyzed the level of transcription of the cellular myc and mos genes in a variety of undifferentiated B cell lymphomas of Burkitt and non-Burkitt type that possess either an 8;14 or an 8;22 translocation. These lines expressed 2- to 5-fold more myc-specific RNA than do B cell lines without a translocation. Tumor cell lines of American origin with an 8;14 or 8;22 translocation expressed similar amounts of myc-specific RNA. Tumor cell lines of African origin contained slightly higher levels of myc-specific RNA than did those of American origin. However, level of expression does not appear to correlate with the presence or absence of Epstein-Barr virus. Therefore, a major increase in the transcription of this gene secondary to translocation is unlikely to be the cause of Burkitt lymphoma. There was no evidence of mos-related transcripts in any of the cell lines tested.<\/jats:p>","DOI":"10.1073\/pnas.80.7.1947","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T05:19:56Z","timestamp":1149052796000},"page":"1947-1950","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":41,"title":["Expression of cellular myc and mos genes in undifferentiated B cell lymphomas of Burkitt and non-Burkitt types."],"prefix":"10.1073","volume":"80","author":[{"given":"R T","family":"Maguire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T S","family":"Robins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S S","family":"Thorgeirsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C A","family":"Heilman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1983,4]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.80.7.1947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T11:45:23Z","timestamp":1649850323000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.80.7.1947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,4]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1983,4]]}},"alternative-id":["10.1073\/pnas.80.7.1947"],"URL":"https:\/\/doi.org\/10.1073\/pnas.80.7.1947","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,4]]},"assertion":[{"value":"1983-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}