{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:36:25Z","timestamp":1788244585415,"version":"build-2803163510"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"17","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:p>The Drosophila learning mutant rutabaga is missing calcium\/calmodulin activation of adenylate cyclase (EC4.6.1.1). The mutation was mapped at a finer resolution to X chromosome bands 12F5-7. By comparing wild-type and mutant cyclase activities, the relative responsiveness of the calcium-sensitive and calcium-insensitive components to different ligands could be determined; the calcium-sensitive fraction of the total cyclase activity was significantly less responsive to guanyl nucleotides and monoamines. The results suggest that the component of cyclase activity that is stimulated by calcium\/calmodulin, possibly a genetically distinct catalytic subunit, is not coupled to the G subunit or the G subunit\/monoamine receptor complex.<\/jats:p>","DOI":"10.1073\/pnas.82.17.5992","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T05:44:39Z","timestamp":1149054279000},"page":"5992-5996","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":92,"title":["Genetic dissection of Drosophila adenylate cyclase."],"prefix":"10.1073","volume":"82","author":[{"given":"M S","family":"Livingstone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1985,9]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.82.17.5992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T11:47:53Z","timestamp":1649850473000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.82.17.5992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9]]},"references-count":0,"journal-issue":{"issue":"17","published-print":{"date-parts":[[1985,9]]}},"alternative-id":["10.1073\/pnas.82.17.5992"],"URL":"https:\/\/doi.org\/10.1073\/pnas.82.17.5992","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,9]]},"assertion":[{"value":"1985-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}