{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:46:59Z","timestamp":1789512419040,"version":"build-2803163510"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"12","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1988,6]]},"abstract":"<jats:p>To elucidate the roles of IgE antibody in host responses to helminth infection, selective IgE-deficient SJA\/9 mice were infected with the nematode parasites Nippostrongylus brasiliensis, which elicits remarkable potentiated IgE production, and Trichinella spiralis, which induces strong anti-Trichinella IgE antibody production in normal mice. The kinetics of blood eosinophilia, worm burden after primary infection, and resistance to secondary infection in SJA\/9 mice were the same in both infections as those in congenic SJL\/J mice used as an IgE-producing control. These results indicate that the host responses examined here operate under IgE-independent mechanisms.<\/jats:p>","DOI":"10.1073\/pnas.85.12.4460","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T06:37:52Z","timestamp":1149057472000},"page":"4460-4462","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["Protective immunity and eosinophilia in IgE-deficient SJA\/9 mice infected with Nippostrongylus brasiliensis and Trichinella spiralis."],"prefix":"10.1073","volume":"85","author":[{"given":"N","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Parasitology, Jikei University School of Medicine, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Katakura","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Jikei University School of Medicine, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Jikei University School of Medicine, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Jikei University School of Medicine, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Ovary","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Jikei University School of Medicine, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1988,6]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.85.12.4460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T12:52:45Z","timestamp":1649854365000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.85.12.4460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,6]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1988,6]]}},"alternative-id":["10.1073\/pnas.85.12.4460"],"URL":"https:\/\/doi.org\/10.1073\/pnas.85.12.4460","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,6]]},"assertion":[{"value":"1988-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}