{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:48:06Z","timestamp":1781110086257,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"13","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:p>The etiology of Alzheimer disease (AD) is unknown. To investigate the transmissibility of AD, the buffy coat of the blood from 11 relatives of AD patients, including 2 with suspicious or early signs of AD, was inoculated intracerebrally into hamsters. In these pilot experiments, 5 individuals produced histologically documented spongiform encephalopathy on primary passage in recipient hamsters. Material from 3 of these positives was serially transmitted in a second passage. The histological alterations observed in the brains of positive hamsters were similar to those seen in experimental Creutzfeldt-Jakob disease (CJD). These transmission results raise the intriguing possibility that CJD-like agents may be involved in at least some forms of AD.<\/jats:p>","DOI":"10.1073\/pnas.85.13.4898","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T06:38:04Z","timestamp":1149057484000},"page":"4898-4901","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":41,"title":["Transmission studies from blood of Alzheimer disease patients and healthy relatives."],"prefix":"10.1073","volume":"85","author":[{"given":"E E","family":"Manuelidis","sequence":"first","affiliation":[{"name":"Section of Neuropathology, Yale University, School of Medicine, New Haven, CT 06510."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"de Figueiredo","sequence":"additional","affiliation":[{"name":"Section of Neuropathology, Yale University, School of Medicine, New Haven, CT 06510."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Kim","sequence":"additional","affiliation":[{"name":"Section of Neuropathology, Yale University, School of Medicine, New Haven, CT 06510."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W W","family":"Fritch","sequence":"additional","affiliation":[{"name":"Section of Neuropathology, Yale University, School of Medicine, New Haven, CT 06510."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Manuelidis","sequence":"additional","affiliation":[{"name":"Section of Neuropathology, Yale University, School of Medicine, New Haven, CT 06510."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1988,7]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.85.13.4898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T12:59:29Z","timestamp":1649854769000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.85.13.4898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7]]},"references-count":0,"journal-issue":{"issue":"13","published-print":{"date-parts":[[1988,7]]}},"alternative-id":["10.1073\/pnas.85.13.4898"],"URL":"https:\/\/doi.org\/10.1073\/pnas.85.13.4898","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,7]]},"assertion":[{"value":"1988-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}