{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:30:21Z","timestamp":1791192621233,"version":"4.1.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"16","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1988,8]]},"abstract":"<jats:p>Transgenic mice carrying a fusion gene in which the mouse immunoglobulin enhancer has been inserted into an otherwise normal human c-myc gene develop a narrow spectrum of pre-B-cell lymphomas. Tumor occurrence is correlated with expression of the transgene in organs in which large numbers of pre-B cells predominate. These tumors, which arise stochastically, are virtually all lymphoblastic lymphomas of the pre-B-cell type. Evidently the isolated enhancer targets oncogene expression and tumorigenesis to the early B-cell population in preference to more mature B-cell populations. The transgene also confers enhanced in vitro growth properties on nontransformed pre-B cells as observed in bone marrow cultures derived from transgenic animals. These cultured cells represent a population in which the activating function of c-myc can be uncoupled from secondary oncogenic events occurring in vivo.<\/jats:p>","DOI":"10.1073\/pnas.85.16.6047","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T06:40:46Z","timestamp":1149057646000},"page":"6047-6051","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":75,"title":["Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model."],"prefix":"10.1073","volume":"85","author":[{"given":"E V","family":"Schmidt","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P K","family":"Pattengale","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Weir","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Leder","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1988,8]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.85.16.6047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:00:56Z","timestamp":1649854856000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.85.16.6047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,8]]},"references-count":0,"journal-issue":{"issue":"16","published-print":{"date-parts":[[1988,8]]}},"alternative-id":["10.1073\/pnas.85.16.6047"],"URL":"https:\/\/doi.org\/10.1073\/pnas.85.16.6047","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,8]]},"assertion":[{"value":"1988-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}