{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:59:38Z","timestamp":1781103578453,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"4","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1988,2]]},"abstract":"<jats:p>Deletions in chromosome 7 of the mouse affect the expression of the metallothionein gene Mt-1, which maps on chromosome 8, and steady-state levels of Mt-1 mRNA are reduced to 15-40% of normal in livers of newborn mice homozygous for either the c3H or c14CoS deletion. Glucocorticoids fail to induce hepatic Mt-1 mRNA levels in deletion homozygotes in contrast to normal littermates. However, zinc chloride is effective in inducing Mt-1 mRNA levels in livers of deletion homozygotes as well as of their normal littermates. Other tissues (e.g., kidney and intestine) of deletion homozygotes express basal levels of Mt-1 mRNA higher than those of normal littermates. In the intestine these are furthermore inducible by both hormonal and metal agents. Thus, loss of inducibility of the Mt-1 gene in deletion homozygotes concerns glucocorticoids only and is furthermore restricted to specific cell types (i.e., hepatocytes). The trans-acting factor(s) normally encoded in the deleted region of chromosome 7 appears to be instrumental in conferring on the metallothionein gene in hepatocytes the essential competence to respond to hormonal inducing signals.<\/jats:p>","DOI":"10.1073\/pnas.85.4.1161","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T06:49:55Z","timestamp":1149058195000},"page":"1161-1164","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":13,"title":["Metallothionein mRNA expression in mice homozygous for chromosomal deletions around the albino locus."],"prefix":"10.1073","volume":"85","author":[{"given":"D","family":"DeFranco","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Pittsburgh, PA 15260."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"S M","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Pittsburgh, PA 15260."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Leonard","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Pittsburgh, PA 15260."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Gluecksohn-Waelsch","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Pittsburgh, PA 15260."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1988,2]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.85.4.1161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T12:37:13Z","timestamp":1649853433000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.85.4.1161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,2]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,2]]}},"alternative-id":["10.1073\/pnas.85.4.1161"],"URL":"https:\/\/doi.org\/10.1073\/pnas.85.4.1161","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,2]]},"assertion":[{"value":"1988-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}