{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:21:49Z","timestamp":1781104909151,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"8","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1988,4]]},"abstract":"<jats:p>Comparison of the amino acid sequences of the deoxythymidine kinases of herpes simplex (HSV) and of marmoset herpes viruses (MHV) suggests a divergence time of 8 to 10 million years ago for HSV-1 and -2. Like MHV, HSV-1 and -2 cause local infections in their natural hosts, and direct contact between two individuals during the brief period of infectivity is needed for transmission. Because B virus, a nearer relative of HSV, depends on both oral and genital routes of transmission, we postulate that ancestral HSV (aHSV) was similar, and that for HSV-1 and -2 to diverge, genital and oral sites had to become microbiologically somewhat isolated from each other, while oral--oral and genital--genital contact had to be facilitated to maintain both aHSV strains. We propose that acquisition of continual sexual attractiveness by the ancestral human female and the adoption of close face-to-face mating, two hallmarks of human sexual behavior, provided the conditions for the divergence.<\/jats:p>","DOI":"10.1073\/pnas.85.8.2658","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T06:53:09Z","timestamp":1149058389000},"page":"2658-2661","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":41,"title":["Sequence analyses of herpesviral enzymes suggest an ancient origin for human sexual behavior."],"prefix":"10.1073","volume":"85","author":[{"given":"G A","family":"Gentry","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Mississippi Medical Center, Jackson 39216."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Mississippi Medical Center, Jackson 39216."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Alford","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Mississippi Medical Center, Jackson 39216."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Nevins","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Mississippi Medical Center, Jackson 39216."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1988,4]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.85.8.2658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T12:46:19Z","timestamp":1649853979000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.85.8.2658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,4]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1988,4]]}},"alternative-id":["10.1073\/pnas.85.8.2658"],"URL":"https:\/\/doi.org\/10.1073\/pnas.85.8.2658","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,4]]},"assertion":[{"value":"1988-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}