{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:45:38Z","timestamp":1791179138110,"version":"4.1.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"11","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1989,6]]},"abstract":"<jats:p>The T-cell receptor (TCR) alpha\/delta chain locus on chromosome 14q11 is nonrandomly involved in translocations and inversions in human T-cell neoplasms. We have analyzed three acute T-lymphoblastic leukemia samples carrying a t(10;14)(q24;q11) chromosome translocation by means of somatic cell hybrids and molecular cloning. In all cases studied the translocation splits the TCR delta chain locus. Somatic cell hybrids containing the human 10q+ chromosome resulting from the translocation retain the human terminal deoxynucleotidyltransferase gene mapped at 10q23-q24 and the diversity and joining, D delta 2-J delta 1, regions of the TCR delta chain, but not the V alpha region (variable region of the TCR alpha chain), demonstrating that the split occurred within the V alpha-D delta 2 region. Molecular cloning of the breakpoint junctions revealed that the TCR delta chain sequences involved are made from the D delta 2 segment. The chromosome breakpoints are clustered within a region of approximately 263 base pairs of chromosome 10. The results suggest that the translocation of the TCR delta chain locus to a locus on 10q, which we have designated TCL3, results in deregulation of this putative oncogene, leading to acute T-cell leukemia.<\/jats:p>","DOI":"10.1073\/pnas.86.11.4161","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T06:56:42Z","timestamp":1149058602000},"page":"4161-4165","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":40,"title":["Clustering of breakpoints on chromosome 10 in acute T-cell leukemias with the t(10;14) chromosome translocation."],"prefix":"10.1073","volume":"86","author":[{"given":"J","family":"Kagan","sequence":"first","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L R","family":"Finger","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Letofsky","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Finan","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C","family":"Nowell","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Croce","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1989,6]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.86.11.4161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T12:58:34Z","timestamp":1649854714000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.86.11.4161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1989,6]]}},"alternative-id":["10.1073\/pnas.86.11.4161"],"URL":"https:\/\/doi.org\/10.1073\/pnas.86.11.4161","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,6]]},"assertion":[{"value":"1989-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}