{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:28:34Z","timestamp":1781105314404,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"12","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1989,6]]},"abstract":"<jats:p>To date, two classes of mouse major urinary protein (MUP)-encoding genes have been described, the expressed genes and the intervening-sequence-containing pseudogenes. The data presented in this paper define a third class, the silent Mup genes, which are potentially functional but appear not to be expressed under normal circumstances. We describe a MUP subfamily (Mup-1.5) containing two genes, Mup-1.5a and Mup-1.5b, that are nearly identical, differing at only three positions (greater than 99.9% identity) over the entire 4-kilobase (kb) transcription unit and approximately 1 kb of flanking DNA. The similarity between these two genes extends over greater than 35 kb. Using specific oligonucleotides, we have shown that the 5a gene is expressed in BALB\/cByJ mice, primarily in the submaxillary gland, whereas the 5b gene is not expressed. However, we found that when a 9.4-kb DNA fragment containing the Mup-1.5b gene was introduced into the mouse germ line, mice in two of the four transgenic lines expressed this gene at a high level and with the tissue-specificity characteristic of the Mup-1.5a gene. These results suggest that the inactivity of the endogenous Mup-1.5b gene is due not to a lack of functional positive regulatory elements, but to long-range, inhibitory position effects.<\/jats:p>","DOI":"10.1073\/pnas.86.12.4584","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T06:56:58Z","timestamp":1149058618000},"page":"4584-4588","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":11,"title":["Silent genes in the mouse major urinary protein gene family."],"prefix":"10.1073","volume":"86","author":[{"given":"Y","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Developmental and Structural Biology, City of New York, NY 10016."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H J","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Developmental and Structural Biology, City of New York, NY 10016."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Shahan","sequence":"additional","affiliation":[{"name":"Department of Developmental and Structural Biology, City of New York, NY 10016."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Developmental and Structural Biology, City of New York, NY 10016."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Costantini","sequence":"additional","affiliation":[{"name":"Department of Developmental and Structural Biology, City of New York, NY 10016."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Derman","sequence":"additional","affiliation":[{"name":"Department of Developmental and Structural Biology, City of New York, NY 10016."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1989,6]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.86.12.4584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:01:07Z","timestamp":1649854867000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.86.12.4584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1989,6]]}},"alternative-id":["10.1073\/pnas.86.12.4584"],"URL":"https:\/\/doi.org\/10.1073\/pnas.86.12.4584","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,6]]},"assertion":[{"value":"1989-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}