{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:38:45Z","timestamp":1790735925396,"version":"4.1.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"2","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:p>We have detected and cloned two rearrangements in the T-cell receptor alpha locus from a clone of somatic cell hybrids carrying a t(14;14)(q11;q32) chromosomal translocation derived from an ataxia telangiectasia patient with T-cell chronic lymphocytic leukemia. The T-cell clone carrying the t(14;14) chromosomal translocation was known to be present for greater than 10 years before the onset of overt leukemia. One molecular rearrangement of the T-cell receptor alpha locus corresponded to a functional variable-joining region (V-J) joining, whereas the other derived from the breakpoint of the t(14;14)(q11;q32) translocation. Chromosomal in situ hybridization of the probe derived from the t(14;14) breakpoint localized the breakpoint region to 14q32.1, apparently the same region that is involved in another ataxia telangiectasia characteristic chromosome translocation, t(7;14)(q35;q32). The 14q32.1 breakpoint is at least 10,000 kilobase pairs (kbp) centromeric to the immunoglobulin heavy chain locus. Sequence analysis of the breakpoint indicates the involvement of a J alpha sequence during the translocation. Comigration of high-molecular weight DNA fragments involved with t(7;14) and t(14;14) translocations suggests the presence of a cluster of breakpoints in the 14q32.1 region, the site of a putative oncogene, TCL1.<\/jats:p>","DOI":"10.1073\/pnas.86.2.602","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T07:05:40Z","timestamp":1149059140000},"page":"602-606","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":71,"title":["Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient."],"prefix":"10.1073","volume":"86","author":[{"given":"G","family":"Russo","sequence":"first","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Isobe","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Gatti","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Finan","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Batuman","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Huebner","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C","family":"Nowell","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Croce","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1989,1]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.86.2.602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T12:44:48Z","timestamp":1649853888000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.86.2.602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1073\/pnas.86.2.602"],"URL":"https:\/\/doi.org\/10.1073\/pnas.86.2.602","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1]]},"assertion":[{"value":"1989-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}