{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:35:41Z","timestamp":1781109341219,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"21","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:p>We report that treatment of 2.2.15, a human hepatoblastoma-derived cell line in which hepatitis B virus is actively replicating, with the carbocyclic analogue of 2'-deoxyguanosine [Shealy, Y. F., O'Dell, C. A., Shannon, W. M. &amp; Arnett, G. (1984) J. Med. Chem. 27, 1416-1421] resulted in the nearly complete cessation of viral replication, as monitored by the absence of both intracellular episomal and secreted viral DNAs and by the absence of viral DNA polymerase activity. The drug was nontoxic in concentrations up to 200 times the minimum effective inhibitory concentration.<\/jats:p>","DOI":"10.1073\/pnas.86.21.8541","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T07:07:17Z","timestamp":1149059237000},"page":"8541-8544","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":42,"title":["Inhibition of the replication of hepatitis B virus by the carbocyclic analogue of 2'-deoxyguanosine."],"prefix":"10.1073","volume":"86","author":[{"given":"P M","family":"Price","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Mount Sinai School of Medicine, New York, NY 10029."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Mount Sinai School of Medicine, New York, NY 10029."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Acs","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Mount Sinai School of Medicine, New York, NY 10029."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1989,11]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.86.21.8541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T12:42:45Z","timestamp":1649853765000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.86.21.8541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":0,"journal-issue":{"issue":"21","published-print":{"date-parts":[[1989,11]]}},"alternative-id":["10.1073\/pnas.86.21.8541"],"URL":"https:\/\/doi.org\/10.1073\/pnas.86.21.8541","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,11]]},"assertion":[{"value":"1989-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}