{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:45:30Z","timestamp":1781106330445,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"5","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:p>A rat model of severe nerve ischemia was used to study the effects of ischemia and reperfusion on nerve conduction, blood flow, and the integrity of the blood-nerve barrier. Conduction failure was consistently found in the sciatic-tibial nerve during 1- and 3-hr ischemic periods. Recovery of the compound muscle action potential was prompt and complete upon reperfusion following 1 hr of ischemia. However, after 3 hr of ischemia, recovery in the proximal portion of the sciatic nerve was less than 10%, and conduction block occurred in the distal portion of the nerve. Nerve blood flow was restored to only 55% and 45% of resting values following 1 and 3 hr, respectively, of ischemia and did not recover even after 2 hr of reperfusion. The blood-nerve barrier was not statistically impaired to the passage of [14C]sucrose following 1 hr of ischemia but was significantly impaired after 3 hr of ischemia. The permeability-surface area product was consistently greater following 1 hr of reperfusion than during the immediate reperfusion period. These data indicate that severe ischemia of peripheral nerve results in reperfusion injury, conduction block, and blood-nerve barrier disruption. Microvascular events, which may occur during reperfusion, may be important in amplifying the nerve fiber damage that began during ischemia.<\/jats:p>","DOI":"10.1073\/pnas.86.5.1639","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T07:13:59Z","timestamp":1149059639000},"page":"1639-1642","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":121,"title":["Ischemic and reperfusion injury of rat peripheral nerve."],"prefix":"10.1073","volume":"86","author":[{"given":"J D","family":"Schmelzer","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Foundation, Rochester, MN 55905."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D W","family":"Zochodne","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Foundation, Rochester, MN 55905."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P A","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Foundation, Rochester, MN 55905."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1989,3]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.86.5.1639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T12:45:25Z","timestamp":1649853925000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.86.5.1639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,3]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989,3]]}},"alternative-id":["10.1073\/pnas.86.5.1639"],"URL":"https:\/\/doi.org\/10.1073\/pnas.86.5.1639","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,3]]},"assertion":[{"value":"1989-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}