{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:45:37Z","timestamp":1791179137981,"version":"4.1.0"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"8","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:p>We cloned the t(10;14) recurrent translocation from CD3-negative T-cell acute lymphoblastic leukemia cells. The breakpoint at 14q11 involved an intermediate rearrangement of the delta T-cell receptor locus, suggesting that the translocation arose at the time of antigen receptor assemblage. Translocation introduced chromosome segment 10q24 as proven by hybridization of a breakpoint-derived probe to flow-sorted chromosomes and metaphase chromosomes. Two t(10;14) breakpoints were clustered within a 600-base-pair region of 10q24 but no heptamer-spacer-nonamer motifs resembling T-cell receptor\/immunoglobulin rearrangement signals were noted at the breakpoint. A locus distinct from terminal deoxynucleotidyltransferase was found at 10q24. Evolutionarily conserved regions surrounding the 10q24 breakpoint were examined for transcriptional activity. A region telomeric to the 10q24 breakpoint, expected to translocate to the der(14) chromosome, recognized an abundant 2.9-kilobase RNA in a t(10;14) T-cell leukemia. This locus was not active in a variety of other normal and neoplastic T cells, arguing that it was deregulated by the introduction of the T-cell receptor. This locus is a candidate for a putative protooncogene, TCL3, involved in T-cell neoplasia.<\/jats:p>","DOI":"10.1073\/pnas.87.8.3161","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T07:38:04Z","timestamp":1149061084000},"page":"3161-3165","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24."],"prefix":"10.1073","volume":"87","author":[{"given":"M","family":"Zutter","sequence":"first","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R D","family":"Hockett","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C W","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E A","family":"McGuire","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bloomstone","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C C","family":"Morton","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L L","family":"Deaven","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W M","family":"Crist","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"Korsmeyer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1990,4]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.87.8.3161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:06:00Z","timestamp":1649855160000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.87.8.3161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1990,4]]}},"alternative-id":["10.1073\/pnas.87.8.3161"],"URL":"https:\/\/doi.org\/10.1073\/pnas.87.8.3161","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,4]]},"assertion":[{"value":"1990-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}